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    pdeD putative c-di-GMP phosphodiesterase PdeD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946336, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pdeD
    Official Full Name
    putative c-di-GMP phosphodiesterase PdeD
    Primary source
    ECOCYC:G6996
    Locus tag
    b1815
    See related
    ASAP:ABE-0006043
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1813; yoaD
    Summary
    Mutant has increased aggregation. [More information is available at EcoGene: EG13516]. YoaD is a member of the EAL family of phosphodiesterases, which may be responsible for degradation of the signalling molecule cyclic di-GMP . [More information is available at EcoCyc: G6996].
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    Genomic context

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    Sequence:
    NC_000913.3 (1898427..1900025)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative NUDIX hydrolase with low 3-phosphohydroxypyruvate phosphatase activity Neighboring gene L-serine deaminase I Neighboring gene TerC family inner membrane protein YoaE Neighboring gene protein YoaL Neighboring gene mannose-specific PTS enzyme IIAB component

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene expression regulation by the Curli activator CsgD protein: modulation of cellulose biosynthesis and control of negative determinants for microbial adhesion. Brombacher E, et al. J Bacteriol, 2006 Mar. PMID 16513732, Free PMC Article
    2. Transmembrane redox control and proteolysis of PdeC, a novel type of c-di-GMP phosphodiesterase. Herbst S, et al. EMBO J, 2018 Apr 13. PMID 29514851, Free PMC Article
    3. C-di-GMP: the dawning of a novel bacterial signalling system. Römling U, et al. Mol Microbiol, 2005 Aug. PMID 16045609
    4. Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli. Sommerfeldt N, et al. Microbiology (Reading), 2009 Apr. PMID 19332833
    5. Characterization of the rdar morphotype, a multicellular behaviour in Enterobacteriaceae. Römling U. Cell Mol Life Sci, 2005 Jun. PMID 15818467, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cyclic-guanylate-specific phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative c-di-GMP phosphodiesterase PdeD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1898427..1900025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416329.4 putative c-di-GMP phosphodiesterase PdeD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416329.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GP42
      Conserved Domains (2) summary
      PRK10551
      Location:10 → 511
      PRK10551; cyclic di-GMP phosphodiesterase
      COG2200
      Location:266 → 518
      EAL; EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version

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