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    cheW chemotaxis protein CheW [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946400, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cheW
    Official Full Name
    chemotaxis protein CheW
    Primary source
    ECOCYC:EG10149
    Locus tag
    b1887
    See related
    ASAP:ABE-0006292
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1888
    Summary
    Flagellar regulon. [More information is available at EcoGene: EG10149]. CheW is involved in the transmission of sensory signals from the methyl-accepting chemotaxis proteins (MCPs) to the flagellar motors. [More information is available at EcoCyc: EG10149].
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    Genomic context

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    Sequence:
    NC_000913.3 (1972836..1973339, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene methyl-accepting chemotaxis protein Tap Neighboring gene methyl-accepting chemotaxis protein Tar Neighboring gene chemotaxis protein CheA Neighboring gene motility protein B Neighboring gene motility protein A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Receptor-mediated protein kinase activation and the mechanism of transmembrane signaling in bacterial chemotaxis. Liu Y, et al. EMBO J, 1997 Dec 15. PMID 9405352, Free PMC Article
    2. Solution structure of the bacterial chemotaxis adaptor protein CheW from Escherichia coli. Li Y, et al. Biochem Biophys Res Commun, 2007 Sep 7. PMID 17631272
    3. Role of the CheW protein in bacterial chemotaxis: overexpression is equivalent to absence. Sanders DA, et al. J Bacteriol, 1989 Nov. PMID 2681160, Free PMC Article
    4. Role of CheW protein in coupling membrane receptors to the intracellular signaling system of bacterial chemotaxis. Liu JD, et al. Proc Natl Acad Sci U S A, 1989 Nov. PMID 2682657, Free PMC Article
    5. Insights into the organization and dynamics of bacterial chemoreceptor clusters through in vivo crosslinking studies. Studdert CA, et al. Proc Natl Acad Sci U S A, 2005 Oct 25. PMID 16230637, Free PMC Article

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Engineered chemotaxis core signaling units indicate a constrained kinase-off state.
      Title: Engineered chemotaxis core signaling units indicate a constrained kinase-off state.
    2. CheW truncated variants are able to drive chemotaxis behavior through activation and control of the CheA kinase. CheA control and networking activities reside in separate domains of CheW protein.
      Title: Truncated, Non-networking Versions of the Coupling Protein CheW Retain Chemoreceptor Control of Kinase CheA.
    3. the Tar(FO) modules demonstrate that trimerized signaling tips self-associate, bind CheA and CheW, and facilitate conversion of CheA to an active conformation.
      Title: Preformed Soluble Chemoreceptor Trimers That Mimic Cellular Assembly States and Activate CheA Autophosphorylation.
    4. Results suggest that ligand binding triggers changes in the receptor that alter its signalling contacts with CheW.
      Title: Signalling-dependent interactions between the kinase-coupling protein CheW and chemoreceptors in living cells.
    5. Data show that even though static homology models of CheW may be partially structurally different from their corresponding experimentally determined structures, the conformational space they can access through their dynamic variations can be similar.
      Title: Homology modeling of the CheW coupling protein of the chemotaxis signaling complex.
    6. Co-overexpression of Tsr, CheA, and CheW yields hexagonal Arrays.
      Title: New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography.
    7. analysis of CheA and CheW protein architecture and their role in bacterial chemotaxis
      Title: Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins.
    8. The exchange of CheA and CheW at receptor clusters shows a modest dependency on the receptor modification.
      Title: Effects of receptor modification and temperature on dynamics of sensory complexes in Escherichia coli chemotaxis.
    9. Results identified CheW surfaces responsible for CheA-Tsr interaction.
      Title: Protein footprinting in a complex milieu: identifying the interaction surfaces of the chemotaxis adaptor protein CheW.
    10. The 2[to]2[to]1 organization is the core structural and functional unit of chemotaxis signaling complexes and hexagonal arrays characteristic of signaling complexes may be built from this unit.
      Title: Core unit of chemotaxis signaling complexes.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within aerotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of post-translational protein modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of methyl accepting chemotaxis protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chemotaxis protein CheW

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1972836..1973339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416401.1 chemotaxis protein CheW [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416401.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A418GHT6
      Conserved Domains (1) summary
      PRK10612
      Location:1 → 167
      PRK10612; chemotaxis protein CheW
    Nucleotide Protein
    Heading Accession and Version

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