U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sbmC DNA gyrase inhibitor [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946546, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sbmC
    Official Full Name
    DNA gyrase inhibitor
    Primary source
    ECOCYC:EG11892
    Locus tag
    b2009
    See related
    ASAP:ABE-0006670
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dgi; ECK2003; gyrI; yeeB
    Summary
    sbmC has been demonstrated to to have a CRP-S promoter co-regulated by both Crp and Sxy (Cameron, 2006). [More information is available at EcoGene: EG11892]. SbmC is an inhibitor of DNA gyrase-mediated DNA supercoiling that inhibits the enzyme activity at an early step . [More information is available at EcoCyc: EG11892].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2080789..2081262, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YoeJ Neighboring gene putative transporter YeeA Neighboring gene D-alanyl-D-alanine carboxypeptidase DacD Neighboring gene exodeoxyribonuclease I

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Chromosomally encoded gyrase inhibitor GyrI protects Escherichia coli against DNA-damaging agents. Chatterji M, et al. Arch Microbiol, 2003 Nov. PMID 13680098
    2. The Escherichia coli SOS gene sbmC is regulated by H-NS and RpoS during the SOS induction and stationary growth phase. Oh TJ, et al. Biochem Biophys Res Commun, 2001 Nov 9. PMID 11689018
    3. [DNA gyrase inhibitor (GyrI) of Escherichia coli]. Nakanishi A, et al. Seikagaku, 1999 Jun. PMID 10432838
    4. sbmC, a stationary-phase induced SOS Escherichia coli gene, whose product protects cells from the DNA replication inhibitor microcin B17. Baquero MR, et al. Mol Microbiol, 1995 Oct. PMID 8709849
    5. Identification of DNA gyrase inhibitor (GyrI) in Escherichia coli. Nakanishi A, et al. J Biol Chem, 1998 Jan 23. PMID 9442027

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Identification of DNA gyrase inhibitor (GyrI) in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA gyrase inhibitor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2080789..2081262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416513.1 DNA gyrase inhibitor [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416513.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN3IHP9
      Conserved Domains (1) summary
      PRK10016
      Location:1 → 156
      PRK10016; DNA gyrase inhibitor SbmC
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.