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    wzzB O-antigen co-polymerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946553, updated on 17-Dec-2024

    Summary

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    Official Symbol
    wzzB
    Official Full Name
    O-antigen co-polymerase
    Primary source
    ECOCYC:G7090
    Locus tag
    b2027
    See related
    ASAP:ABE-0006731
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cld; ECK2022; rol; wzz
    Summary
    In Escherichia coli strains O8 and O9, the orthologous Wzz protein was shown to control the length of the O-antigen component of lipopolysaccharide . [More information is available at EcoCyc: G7090].
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    Genomic context

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    Sequence:
    NC_000913.3 (2097321..2098301, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene imidazole glycerol phosphate synthase subunit HisH Neighboring gene 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase Neighboring gene imidazole glycerol phosphate synthase subunit HisF Neighboring gene putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase Neighboring gene UDP-glucose 6-dehydrogenase Neighboring gene 6-phosphogluconate dehydrogenase, decarboxylating

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of a full-length bacterial polysaccharide co-polymerase. Wiseman B, et al. Nat Commun, 2021 Jan 14. PMID 33446644, Free PMC Article
    2. Regulation by a novel protein of the bimodal distribution of lipopolysaccharide in the outer membrane of Escherichia coli. Batchelor RA, et al. J Bacteriol, 1991 Sep. PMID 1715860, Free PMC Article
    3. Repeat unit polysaccharides of bacteria: a model for polymerization resembling that of ribosomes and fatty acid synthetase, with a novel mechanism for determining chain length. Bastin DA, et al. Mol Microbiol, 1993 Mar. PMID 7682279
    4. A Wzz (Cld) protein determines the chain length of K lipopolysaccharide in Escherichia coli O8 and O9 strains. Franco AV, et al. J Bacteriol, 1996 Apr. PMID 8606163, Free PMC Article
    5. Quaternary structure of WzzB and WzzE polysaccharide copolymerases. Kalynych S, et al. Protein Sci, 2015 Jan. PMID 25307743, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure of a full-length bacterial polysaccharide co-polymerase.
      Title: Structure of a full-length bacterial polysaccharide co-polymerase.
    2. E.coli WzzB and WzzE Polysaccharide Copolymerases form octameric homo-oligomeric complexes.
      Title: Quaternary structure of WzzB and WzzE polysaccharide copolymerases.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    O-antigen co-polymerase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2097321..2098301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416531.4 O-antigen co-polymerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416531.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9ATF2, B1B4Q1
      Conserved Domains (1) summary
      PRK15471
      Location:1 → 326
      PRK15471; chain length determinant protein WzzB; Provisional
    Nucleotide Protein
    Heading Accession and Version

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