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    yfaU 2-keto-3-deoxy-L-rhamnonate aldolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948054, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yfaU
    Official Full Name
    2-keto-3-deoxy-L-rhamnonate aldolase
    Primary source
    ECOCYC:G7158
    Locus tag
    b2245
    See related
    ASAP:ABE-0007431
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2238
    Summary
    2-keto-3-deoxy-L-rhamnonate aldolase also performs a retroaldol reaction on the other products of RhamD 2-keto-3-deoxy-l-mannonate and 2-keto-3-deoxy-l-lyxonate indicating a coupled pathway of assimilation of the RhamD substrates which are likely to be imported using the neighboring transporter homolog YfaV; all three genes appear to be in a yfaXWVU operon with the YfaX predicted regulator (Rea, 2008). [More information is available at EcoGene: EG14083]. YfaU is a 2-keto-3-deoxy-L-rhamnonate aldolase which catalyzes a retro-aldol reaction with somewhat relaxed substrate specificity . [More information is available at EcoCyc: G7158].
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    Genomic context

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    Sequence:
    NC_000913.3 (2358042..2358845, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene inactive recombination-promoting nuclease-like protein RpnE Neighboring gene pseudo Neighboring gene putative transporter YfaV Neighboring gene L-rhamnonate dehydratase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression, purification, crystallization and preliminary characterization of an HHED aldolase homologue from Escherichia coli K12. Wright A, et al. Acta Crystallogr D Biol Crystallogr, 2002 Dec. PMID 12454498
    2. Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12. Rea D, et al. Biochemistry, 2008 Sep 23. PMID 18754683
    3. Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase. Rakus JF, et al. Biochemistry, 2008 Sep 23. PMID 18754693, Free PMC Article
    4. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article
    5. The complete genome sequence of Escherichia coli K-12. Blattner FR, et al. Science, 1997 Sep 5. PMID 9278503

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    2-keto-3-deoxy-L-rhamnonate aldolase
    NP_416748.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2358042..2358845 complement
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416748.1 2-keto-3-deoxy-L-rhamnonate aldolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416748.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6D0IBN2, A0A7L7EIU5
      Conserved Domains (1) summary
      PRK10128
      Location:1 → 267
      PRK10128; 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional
    Nucleotide Protein
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