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    arnC undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945275, updated on 3-Dec-2024

    Summary

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    Official Symbol
    arnC
    Official Full Name
    undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
    Primary source
    ECOCYC:G7167
    Locus tag
    b2254
    See related
    ASAP:ABE-0007458
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2247; pmrF; yfbF
    Summary
    Involved in the modification of lipid A phosphates with aminoarabinose that is required for polymyxin B and cationic antimicrobial peptide resistance. [More information is available at EcoGene: EG14090]. ArnC is an undecaprenyl transferase that acts in a pathway which modifies lipid A phosphates with 4-amino-4-deoxy-L-arabinose (L-Ara4N), causing increased resistance to polymyxin . [More information is available at EcoCyc: G7167].
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    Genomic context

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    Sequence:
    NC_000913.3 (2367071..2368039)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative lipopolysaccharide core heptose(II)-phosphate phosphatase Neighboring gene UDP-4-amino-4-deoxy-L-arabinose aminotransferase Neighboring gene fused UDP-4-amino-4-deoxy-L-arabinose formyltransferase/UDP-glucuronate dehydrogenase Neighboring gene putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD Neighboring gene lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnE subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oxidative decarboxylation of UDP-glucuronic acid in extracts of polymyxin-resistant Escherichia coli. Origin of lipid a species modified with 4-amino-4-deoxy-L-arabinose. Breazeale SD, et al. J Biol Chem, 2002 Jan 25. PMID 11706007
    2. Lipopolysaccharides of polymyxin B-resistant mutants of Escherichia coli are extensively substituted by 2-aminoethyl pyrophosphate and contain aminoarabinose in lipid A. Nummila K, et al. Mol Microbiol, 1995 Apr. PMID 7565089
    3. Molecular basis of the magnesium deprivation response in Salmonella typhimurium: identification of PhoP-regulated genes. Soncini FC, et al. J Bacteriol, 1996 Sep. PMID 8752324, Free PMC Article
    4. A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose. Breazeale SD, et al. J Biol Chem, 2005 Apr 8. PMID 15695810
    5. Lipid A modifications characteristic of Salmonella typhimurium are induced by NH4VO3 in Escherichia coli K12. Detection of 4-amino-4-deoxy-L-arabinose, phosphoethanolamine and palmitate. Zhou Z, et al. J Biol Chem, 1999 Jun 25. PMID 10373459

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
    NP_416757.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2367071..2368039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416757.1 undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416757.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A831GQ32
      Conserved Domains (1) summary
      PRK10714
      Location:3 → 321
      PRK10714; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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