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    sixA phosphohistidine phosphatase SixA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946815, updated on 3-Dec-2024

    Summary

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    Official Symbol
    sixA
    Official Full Name
    phosphohistidine phosphatase SixA
    Primary source
    ECOCYC:G7211
    Locus tag
    b2340
    See related
    ASAP:ABE-0007720
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2334; yfcW
    Summary
    SixA overexpression also interferes with BarA Hpt function (Ogina, 1998). [More information is available at EcoGene: EG14126]. The sixA gene encodes a phosphohistidine phosphatase that specifically removes the phosphoryl group from the His717 residue of ArcB . [More information is available at EcoCyc: G7211].
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    Genomic context

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    Sequence:
    NC_000913.3 (2456327..2456812, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene putative fimbrial protein YfcV Neighboring gene 3-hydroxyacyl-CoA dehydrogenase FadJ Neighboring gene 3-ketoacyl-CoA thiolase FadI Neighboring gene DUF406 domain-containing protein YfcZ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The phosphohistidine phosphatase SixA dephosphorylates the phosphocarrier NPr. Schulte JE, et al. J Biol Chem, 2021 Jan-Jun. PMID 33199374, Free PMC Article
    2. Crystallographic characterization of a novel protein SixA which exhibits phospho-histidine phosphatase activity in the multistep His-Asp phosphorelay. Hamada K, et al. Acta Crystallogr D Biol Crystallogr, 1999 Jan. PMID 10089421
    3. The Phosphohistidine Phosphatase SixA Targets a Phosphotransferase System. Schulte JE, et al. mBio, 2018 Nov 27. PMID 30482831, Free PMC Article
    4. Crystal structure of the protein histidine phosphatase SixA in the multistep His-Asp phosphorelay. Hamada K, et al. Genes Cells, 2005 Jan. PMID 15670209
    5. An Escherichia coli protein that exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His-Asp phosphorelay. Ogino T, et al. Mol Microbiol, 1998 Feb. PMID 9489669

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein histidine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein histidine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein histidine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein modification process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of phosphorelay signal transduction system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of phosphorelay signal transduction system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphohistidine phosphatase SixA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2456327..2456812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416842.1 phosphohistidine phosphatase SixA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416842.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FP52
      Conserved Domains (1) summary
      PRK10848
      Location:1 → 159
      PRK10848; phosphohistidine phosphatase SixA
    Nucleotide Protein
    Heading Accession and Version

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