U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    csdE sulfur acceptor protein CsdE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947274, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    csdE
    Official Full Name
    sulfur acceptor protein CsdE
    Primary source
    ECOCYC:G7455
    Locus tag
    b2811
    See related
    ASAP:ABE-0009220
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2807; ygdK
    Summary
    CdsE is homologous to SufE. csdAE are a multicopy suppressor of iscS. [More information is available at EcoGene: EG13083]. CsdA and CsdE combine to form the CSD sulfur-generating system. [More information is available at EcoCyc: G7455].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2944542..2944985)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DUF903 domain-containing lipoprotein YgdI Neighboring gene cysteine sulfinate desulfinase Neighboring gene tRNA threonylcarbamoyladenosine dehydratase Neighboring gene membrane-bound lytic murein transglycosylase A

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Insights into the inhibited form of the redox-sensitive SufE-like sulfur acceptor CsdE. Peña-Soler E, et al. PLoS One, 2017. PMID 29045454, Free PMC Article
    2. Structural changes during cysteine desulfurase CsdA and sulfur acceptor CsdE interactions provide insight into the trans-persulfuration. Kim S, et al. J Biol Chem, 2013 Sep 20. PMID 23913692, Free PMC Article
    3. Proteomic analysis of protein-protein interactions within the Cysteine Sulfinate Desulfinase Fe-S cluster biogenesis system. Bolstad HM, et al. J Proteome Res, 2010 Oct 1. PMID 20734996, Free PMC Article
    4. The CsdA cysteine desulphurase promotes Fe/S biogenesis by recruiting Suf components and participates to a new sulphur transfer pathway by recruiting CsdL (ex-YgdL), a ubiquitin-modifying-like protein. Trotter V, et al. Mol Microbiol, 2009 Dec. PMID 20054882
    5. Cysteine sulfinate desulfinase, a NIFS-like protein of Escherichia coli with selenocysteine lyase and cysteine desulfurase activities. Gene cloning, purification, and characterization of a novel pyridoxal enzyme. Mihara H, et al. J Biol Chem, 1997 Sep 5. PMID 9278392

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Herein we present the crystal structure of the oxidized, inactivated CsdE dimer at 2.4 A resolution. The structure sheds light into the activation of the Cys61 nucleophile on its way from a solvent-secluded position in free CsdE to a fully extended conformation in the persulfurated CsdA-CsdE complex.
      Title: Insights into the inhibited form of the redox-sensitive SufE-like sulfur acceptor CsdE.
    2. Data show that that CsdE forms disulfide bonds with multiple proteins.
      Title: Proteomic analysis of protein-protein interactions within the Cysteine Sulfinate Desulfinase Fe-S cluster biogenesis system.
    3. CsdA cysteine desulfurase activity is increased 2-fold in the presence of CsdE. Site-directed mutagenesis showed that residue Cys-61 from CsdE acted as an acceptor site for sulfur provided by cysteine desulfurase activity of CsdA
      Title: Analysis of the heteromeric CsdA-CsdE cysteine desulfurase, assisting Fe-S cluster biogenesis in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sulfur carrier activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cyclic threonylcarbamoyladenosine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    sulfur acceptor protein CsdE

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2944542..2944985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417291.1 sulfur acceptor protein CsdE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417291.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A418GFV9
      Conserved Domains (1) summary
      PRK15019
      Location:1 → 147
      PRK15019; cysteine desulfurase sulfur acceptor subunit CsdE
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.