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    nupG nucleoside:H(+) symporter NupG [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946282, updated on 17-Dec-2024

    Summary

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    Official Symbol
    nupG
    Official Full Name
    nucleoside:H(+) symporter NupG
    Primary source
    ECOCYC:EG10664
    Locus tag
    b2964
    See related
    ASAP:ABE-0009728
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2959; gru
    Summary
    NupG, XapB and YegT are paralogs. [More information is available at EcoGene: EG10664]. NupG is one of two high-affinity nucleoside transporters in Escherichia coli. [More information is available at EcoCyc: EG10664].
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    Genomic context

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    Sequence:
    NC_000913.3 (3105714..3106970)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative Fe(2(+))-trafficking protein Neighboring gene membrane-bound lytic murein transglycosylase C Neighboring gene constitutive ornithine decarboxylase Neighboring gene protein YqgH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular basis for substrate recognition by the bacterial nucleoside transporter NupG. Wang C, et al. J Biol Chem, 2021 Jan-Jun. PMID 33640454, Free PMC Article
    2. Studies on the sequence and structure of the Escherichia coli K-12 nupG gene, encoding a nucleoside-transport system. Westh Hansen SE, et al. Eur J Biochem, 1987 Oct 15. PMID 3311747
    3. Purification and properties of the Escherichia coli nucleoside transporter NupG, a paradigm for a major facilitator transporter sub-family. Xie H, et al. Mol Membr Biol, 2004 Sep-Oct. PMID 15513740
    4. Effect of exercise on the creatine resonances in 1H MR spectra of human skeletal muscle. Kreis R, et al. J Magn Reson, 1999 Apr. PMID 10089169
    5. Nucleoside transport in cells and membrane vesicles from Escherichia coli K12. Munch-Petersen A, et al. J Biol Chem, 1979 May 25. PMID 374403

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular basis for substrate recognition by the bacterial nucleoside transporter NupG.
      Title: Molecular basis for substrate recognition by the bacterial nucleoside transporter NupG.
    2. Oligohistidine-tagged form of NupG from Escherichia coli was purified and characterized.
      Title: Purification and properties of the Escherichia coli nucleoside transporter NupG, a paradigm for a major facilitator transporter sub-family.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cytidine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytidine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleoside transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleoside:proton symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrimidine nucleoside transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uridine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uridine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adenosine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytidine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleoside transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleoside transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine nucleoside transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pyrimidine nucleoside transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within uridine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleoside:H(+) symporter NupG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3105714..3106970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417439.4 nucleoside:H(+) symporter NupG [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417439.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H2Z2B2, A0A1X3JE41, B3Y178, F4T2U2, Q1R761, Q8XCS5
      Conserved Domains (1) summary
      TIGR00889
      Location:1 → 418
      2A0110; nucleoside transporter
    Nucleotide Protein
    Heading Accession and Version

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