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    lptC lipopolysaccharide transport system protein LptC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947722, updated on 17-Dec-2024

    Summary

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    Official Symbol
    lptC
    Official Full Name
    lipopolysaccharide transport system protein LptC
    Primary source
    ECOCYC:G7664
    Locus tag
    b3199
    See related
    ASAP:ABE-0010508
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3188; yrbK
    Summary
    Overexpression causes abnormal biofilm architecture. [More information is available at EcoGene: EG12806]. YrbK is predicted to be an integral membrane component of the LptAB-YrbK ABC transporter. [More information is available at EcoCyc: G7664].
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    Genomic context

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    Sequence:
    NC_000913.3 (3342836..3343411)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transport protein YrbG Neighboring gene D-arabinose 5-phosphate isomerase KdsD Neighboring gene 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC Neighboring gene lipopolysaccharide transport system protein LptA Neighboring gene lipopolysaccharide transport system ATP binding protein LptB Neighboring gene RNA polymerase sigma factor RpoN

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of and lipopolysaccharide binding to the E. coli LptC protein dimer. Schultz KM, et al. Protein Sci, 2018 Feb. PMID 29024084, Free PMC Article
    2. Structure and functional analysis of LptC, a conserved membrane protein involved in the lipopolysaccharide export pathway in Escherichia coli. Tran AX, et al. J Biol Chem, 2010 Oct 22. PMID 20720015, Free PMC Article
    3. Disruption of the E. coli LptC dimerization interface and characterization of lipopolysaccharide and LptA binding to monomeric LptC. Schultz KM, et al. Protein Sci, 2018 Aug. PMID 29672978, Free PMC Article
    4. New insights into the Lpt machinery for lipopolysaccharide transport to the cell surface: LptA-LptC interaction and LptA stability as sensors of a properly assembled transenvelope complex. Sperandeo P, et al. J Bacteriol, 2011 Mar. PMID 21169485, Free PMC Article
    5. The transmembrane α-helix of LptC participates in LPS extraction by the LptB(2) FGC transporter. Wilson A, et al. Mol Microbiol, 2022 Jul. PMID 35678757, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The transmembrane alpha-helix of LptC participates in LPS extraction by the LptB2 FGC transporter.
      Title: The transmembrane α-helix of LptC participates in LPS extraction by the LptB(2) FGC transporter.
    2. Characterized interactions and binding of lipopolysaccharide transport system proteins LptA and LptC thru dimerization and point mutation studies.
      Title: Disruption of the E. coli LptC dimerization interface and characterization of lipopolysaccharide and LptA binding to monomeric LptC.
    3. Characterization of and lipopolysaccharide binding to the E. coli LptC protein dimer has been reported.
      Title: Characterization of and lipopolysaccharide binding to the E. coli LptC protein dimer.
    4. LptC was included in the ABC transporter Lpt protein complex.
      Title: Biochemical characterization of an ABC transporter LptBFGC complex required for the outer membrane sorting of lipopolysaccharides.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glycolipid transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycolipid transfer activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lipopolysaccharide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Gram-negative-bacterium-type cell outer membrane assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipopolysaccharide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in outer membrane-bounded periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transporter complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipopolysaccharide transport system protein LptC
    NP_417666.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3342836..3343411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417666.1 lipopolysaccharide transport system protein LptC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417666.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9ANF2, A0A6L7CG65
      Conserved Domains (1) summary
      PRK10893
      Location:1 → 191
      PRK10893; LPS export ABC transporter periplasmic protein LptC
    Nucleotide Protein
    Heading Accession and Version

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