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    kefB K(+) : H(+) antiporter KefB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947858, updated on 3-Dec-2024

    Summary

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    Official Symbol
    kefB
    Official Full Name
    K(+) : H(+) antiporter KefB
    Primary source
    ECOCYC:EG20110
    Locus tag
    b3350
    See related
    ASAP:ABE-0010949
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3338; trkB
    Summary
    KefB and KefC are two independent glutathione-regulated potassium efflux systems, which play a role in protecting the cell from electrophile toxicity. [More information is available at EcoCyc: EG20110].
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    Genomic context

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    Sequence:
    NC_000913.3 (3478802..3480607, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene FKBP-type peptidyl-prolyl cis-trans isomerase SlyD Neighboring gene DUF2387 domain-containing protein YheV Neighboring gene glutathione-regulated potassium-efflux system ancillary protein KefG Neighboring gene putative ATP-binding protein YheS Neighboring gene putative hydrolase YheT Neighboring gene PF06794 family protein YheU

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activation of potassium efflux from Escherichia coli by glutathione metabolites. Elmore MJ, et al. Mol Microbiol, 1990 Mar. PMID 2192231
    2. Evidence for multiple K+ export systems in Escherichia coli. Bakker EP, et al. J Bacteriol, 1987 Aug. PMID 3301813, Free PMC Article
    3. Roles of the trkB and trkC gene products of Escherichia coli in K+ transport. Booth IR, et al. Biochimie, 1985 Jan. PMID 3888294
    4. Different foci for the regulation of the activity of the KefB and KefC glutathione-gated K+ efflux systems. Ness LS, et al. J Biol Chem, 1999 Apr 2. PMID 10092637
    5. Potassium channel activation by glutathione-S-conjugates in Escherichia coli: protection against methylglyoxal is mediated by cytoplasmic acidification. Ferguson GP, et al. Mol Microbiol, 1995 Sep. PMID 8594323

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione-regulated potassium exporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of potassium:proton antiporter complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    K(+) : H(+) antiporter KefB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3478802..3480607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417809.1 K(+) : H(+) antiporter KefB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417809.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5YDC0
      Conserved Domains (1) summary
      PRK03659
      Location:1 → 600
      PRK03659; glutathione-regulated potassium-efflux system protein KefB; Provisional
    Nucleotide Protein
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