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    hslO molecular chaperone Hsp33 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947178, updated on 17-Dec-2024

    Summary

    Official Symbol
    hslO
    Official Full Name
    molecular chaperone Hsp33
    Primary source
    ECOCYC:G7744
    Locus tag
    b3401
    See related
    ASAP:ABE-0011096
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3388; yrfI
    Summary
    Hsp33 is functionaly down regulated by zinc binding, zinc masks the hydrophobic surfaces under reduced conditions, release of zinc during oxidative induced disulfide bond formation results in the unmasking of the hydrophobic surfaces and partial activation of chaperone function. [More information is available at EcoGene: EG12930]. The Hsp33 protein is expressed under heat shock conditions and activated by oxidative stress. [More information is available at EcoCyc: G7744].
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    Genomic context

    Sequence:
    NC_000913.3 (3529774..3530652)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene purine nucleotidase Neighboring gene heat shock protein Hsp15 Neighboring gene putative transport protein YhgE Neighboring gene phosphoenolpyruvate carboxykinase (ATP)

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within maintenance of unfolded protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein refolding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to heat IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3529774..3530652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417860.2 molecular chaperone Hsp33 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417860.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A776LMP1, A0A8S7TAE9
      Conserved Domains (1) summary
      PRK00114
      Location:3285
      hslO; Hsp33 family molecular chaperone HslO