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    bisC biotin sulfoxide reductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946915, updated on 3-Dec-2024

    Summary

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    Official Symbol
    bisC
    Official Full Name
    biotin sulfoxide reductase
    Primary source
    ECOCYC:EG10124
    Locus tag
    b3551
    See related
    ASAP:ABE-0011597
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3538
    Summary
    BisC is sufficient for growth on Met-S-SO. [More information is available at EcoGene: EG10124]. BisC was first identified as a biotin sulfoxide reductase that reduces a spontaneous oxidation product of biotin, biotin d-sulfoxide (BDS), back to biotin. [More information is available at EcoCyc: EG10124].
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    Genomic context

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    Sequence:
    NC_000913.3 (3714061..3716394, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative outer membrane protein YhjY Neighboring gene 3-methyl-adenine DNA glycosylase I, constitutive Neighboring gene peptidyl-lysine N-acetyltransferase YiaC Neighboring gene PF13488 family lipoprotein YiaD Neighboring gene glyoxylate reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of the system that reduces biotin-d-sulfoxide in Escherichia coli. Dykhuizen D. J Bacteriol, 1973 Aug. PMID 4579877, Free PMC Article
    2. Remnant signal peptides on non-exported enzymes: implications for the evolution of prokaryotic respiratory chains. Ize B, et al. Microbiology (Reading), 2009 Dec. PMID 19778964
    3. Constructing the wonders of the bacterial world: biosynthesis of complex enzymes. Sargent F. Microbiology (Reading), 2007 Mar. PMID 17322183
    4. Alternative gene for biotin sulfoxide reduction in Escherichia coli K-12. del Campillo Campbell A, et al. J Mol Evol, 1996 Feb. PMID 8919859
    5. Cloning and nucleotide sequence of bisC, the structural gene for biotin sulfoxide reductase in Escherichia coli. Pierson DE, et al. J Bacteriol, 1990 Apr. PMID 2180922, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BisC has an essential role in assimilation of oxidized methionines.
      Title: Methionine sulfoxide reduction and assimilation in Escherichia coli: new role for the biotin sulfoxide reductase BisC.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdenum ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molybdenum ion binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables molybdopterin cofactor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in outer membrane-bounded periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    biotin sulfoxide reductase
    NP_418007.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3714061..3716394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418007.3 biotin sulfoxide reductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418007.3

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FV57
      Conserved Domains (1) summary
      TIGR00509
      Location:13 → 775
      bisC_fam; molybdopterin guanine dinucleotide-containing S/N-oxide reductases
    Nucleotide Protein
    Heading Accession and Version

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