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    waaZ lipopolysaccharide core biosynthesis protein WaaZ [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948146, updated on 3-Dec-2024

    Summary

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    Official Symbol
    waaZ
    Official Full Name
    lipopolysaccharide core biosynthesis protein WaaZ
    Primary source
    ECOCYC:EG11426
    Locus tag
    b3624
    See related
    ASAP:ABE-0011854
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3614; rfaZ
    Summary
    The lipopolysaccharide of Escherichia coli K-12 consists of two major components: the hydrophobic lipid A moiety inserted into the outer membrane and the phosphorylated core oligosaccharide . [More information is available at EcoCyc: EG11426].
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    Genomic context

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    Sequence:
    NC_000913.3 (3799345..3800196, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene O-antigen ligase Neighboring gene protein YibY Neighboring gene putative ADP-heptose:LPS heptosyltransferase 4 Neighboring gene lipopolysaccharide core heptose (II) kinase Neighboring gene UDP-glucose:(glucosyl)LPS alpha-1,2-glucosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of the waaZ gene leads to modification of the structure of the inner core region of Escherichia coli lipopolysaccharide, truncation of the outer core, and reduction of the amount of O polysaccharide on the cell surface. Frirdich E, et al. J Bacteriol, 2003 Mar. PMID 12591884, Free PMC Article
    2. SoxRS-mediated lipopolysaccharide modification enhances resistance against multiple drugs in Escherichia coli. Lee JH, et al. J Bacteriol, 2009 Jul. PMID 19376854, Free PMC Article
    3. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Heinrichs DE, et al. Mol Microbiol, 1998 Oct. PMID 9791168
    4. Role of the rfaG and rfaP genes in determining the lipopolysaccharide core structure and cell surface properties of Escherichia coli K-12. Parker CT, et al. J Bacteriol, 1992 Apr. PMID 1348243, Free PMC Article
    5. Role of Escherichia coli K-12 rfa genes and the rfp gene of Shigella dysenteriae 1 in generation of lipopolysaccharide core heterogeneity and attachment of O antigen. Klena JD, et al. J Bacteriol, 1992 Nov. PMID 1385388, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synthesis of different glycoforms is regulated by differential expression of WaaZ (KdoIII transferase) and WaaR (glycosyltransferase).
      Title: Molecular basis of lipopolysaccharide heterogeneity in Escherichia coli: envelope stress-responsive regulators control the incorporation of glycoforms with a third 3-deoxy-α-D-manno-oct-2-ulosonic acid and rhamnose.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide core region biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    lipopolysaccharide core biosynthesis protein WaaZ
    NP_418081.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3799345..3800196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418081.1 lipopolysaccharide core biosynthesis protein WaaZ [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418081.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A6N4W4
      Conserved Domains (1) summary
      PRK09822
      Location:1 → 269
      PRK09822; lipopolysaccharide core biosynthesis protein; Provisional
    Nucleotide Protein
    Heading Accession and Version

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