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    xerC site-specific tyrosine recombinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948355, updated on 3-Dec-2024

    Summary

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    Official Symbol
    xerC
    Official Full Name
    site-specific tyrosine recombinase
    Primary source
    ECOCYC:EG11069
    Locus tag
    b3811
    See related
    ASAP:ABE-0012448
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3806
    Summary
    XerCD acts at the Dif site. [More information is available at EcoGene: EG11069]. XerC is part of the Xer site-specific recombination system . [More information is available at EcoCyc: EG11069].
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    Genomic context

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    Sequence:
    NC_000913.3 (3996287..3997183)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative lipoprotein YifL Neighboring gene diaminopimelate epimerase Neighboring gene DUF484 domain-containing protein YigA Neighboring gene 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase Neighboring gene DNA helicase II

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Xer site-specific recombination. DNA strand rejoining by recombinase XerC. Grainge I, et al. J Biol Chem, 1999 Mar 5. PMID 10037776
    2. Plasmid pSC101 harbors a recombination site, psi, which is able to resolve plasmid multimers and to substitute for the analogous chromosomal Escherichia coli site dif. Cornet F, et al. J Bacteriol, 1994 Jun. PMID 8195072, Free PMC Article
    3. Functional analysis of the C-terminal domains of the site-specific recombinases XerC and XerD. Ferreira H, et al. J Mol Biol, 2003 Jun 27. PMID 12818199
    4. Evidence from terminal recombination gradients that FtsK uses replichore polarity to control chromosome terminus positioning at division in Escherichia coli. Corre J, et al. J Bacteriol, 2002 Jul. PMID 12081949, Free PMC Article
    5. Segregation of the Escherichia coli chromosome terminus. Li Y, et al. Mol Microbiol, 2003 Nov. PMID 14617144

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FtsKgamma interacts with the C-terminal domain of XerD, above a cleft where XerC is thought to bind. We present a model for activation of recombination based on structural data.
      Title: Activation of Xer-recombination at dif: structural basis of the FtsKγ-XerD interaction.
    2. e reveal a physical and functional interaction between Topo IV and the XerCD recombinases acting at the dif site. This interaction is modulated by MatP, a protein involved in the organization of the Ter macrodomain. These results show that Topo IV, XerCD/dif and MatP are part of a network dedicated to the final step of chromosome management during the cell cycle.
      Title: Mapping Topoisomerase IV Binding and Activity Sites on the E. coli Genome.
    3. FtsK translocase has a role in assembly, translocation, and activation of XerCD-dif recombination
      Title: Assembly, translocation, and activation of XerCD-dif recombination by FtsK translocase analyzed in real-time by FRET and two-color tethered fluorophore motion.
    4. Data indicate that the arrival of the FtsK translocase at an initial synaptic complex, forming a transient activated complex in which XerD exchanged a pair of strands to form an Holliday junctions (HJ) intermediate for catalysis by XerC.
      Title: Conformational transitions during FtsK translocase activation of individual XerCD-dif recombination complexes.
    5. N-terminus verified by Edman degradation on complete protein
      Title: Recombination at ColE1 cer requires the Escherichia coli xerC gene product, a member of the lambda integrase family of site-specific recombinases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables site-specific recombinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables site-specific recombinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tyrosine-based site-specific recombinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tyrosine-based site-specific recombinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tyrosine-based site-specific recombinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA integration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA transposition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within plasmid maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plasmid recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in resolution of DNA recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within resolution of DNA recombination intermediates IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in resolution of DNA recombination intermediates IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Holliday junction resolvase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Holliday junction resolvase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    site-specific tyrosine recombinase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3996287..3997183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418256.1 site-specific tyrosine recombinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418256.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AR83
      Conserved Domains (1) summary
      COG4973
      Location:4 → 297
      XerC; Site-specific recombinase XerC [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version

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