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    udp uridine phosphorylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948987, updated on 17-Dec-2024

    Summary

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    Official Symbol
    udp
    Official Full Name
    uridine phosphorylase
    Primary source
    ECOCYC:EG11045
    Locus tag
    b3831
    See related
    ASAP:ABE-0012528
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3825
    Summary
    Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG11045].
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    Genomic context

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    Sequence:
    NC_000913.3 (4016431..4017192)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cobalamin-independent homocysteine transmethylase Neighboring gene putative dienelactone hydrolase Neighboring gene putative recombination limiting protein RmuC Neighboring gene bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinol methylase and demethylmenaquinone methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pyrimidine homeostasis is accomplished by directed overflow metabolism. Reaves ML, et al. Nature, 2013 Aug 8. PMID 23903661, Free PMC Article
    2. Acyclonucleoside analogues consisting of 5- and 5,6-substituted uracils and different acyclic chains: inhibitory properties vs purified E. coli uridine phosphorylase. Drabikowska AK, et al. Z Naturforsch C J Biosci, 1987 Mar. PMID 2954322
    3. Inhibition of uridine phosphorylase from Escherichia coli by benzylacyclouridines. Park KS, et al. Biochem Pharmacol, 1986 Nov 1. PMID 3535805
    4. Crystallization and preliminary X-ray investigation of uridine phosphorylase from Escherichia coli. Cook WJ, et al. J Biol Chem, 1987 Feb 25. PMID 3546298
    5. Uridine phosphorylase from Escherichia coli B.: kinetic studies on the mechanism of catalysis. Vita A, et al. Arch Biochem Biophys, 1983 Oct 15. PMID 6357095

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our preliminary findings suggest that ATP can alter the protein folding and function of enzymes via apparent destabilization. This mechanism may be significant for proteins functioning under conditions of high levels of ATP, such as cancer cell environments.
      Title: ATP alters protein folding and function of Escherichia coli uridine phosphorylase.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Identifying proteins from two-dimensional gels by molecular mass searching of peptide fragments in protein sequence databases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deoxyuridine phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pentosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uridine phosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uridine phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within UMP catabolic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within uridine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uridine phosphorylase
    NP_418275.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4016431..4017192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418275.1 uridine phosphorylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418275.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H3MKB2, A0A192CEN8, B7N2D3
      Conserved Domains (1) summary
      PRK11178
      Location:4 → 253
      PRK11178; uridine phosphorylase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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