U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tpiA triose-phosphate isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948409, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tpiA
    Official Full Name
    triose-phosphate isomerase
    Primary source
    ECOCYC:EG11015
    Locus tag
    b3919
    See related
    ASAP:ABE-0012799
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3911; tpi
    Summary
    Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG11015].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (4110740..4111507, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene sulfate/thiosulfate ABC transporter periplasmic binding protein Sbp Neighboring gene CDP-diacylglycerol diphosphatase Neighboring gene DUF1454 domain-containing protein YiiQ Neighboring gene DUF805 domain-containing protein YiiR

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Nucleotide sequence of the triose phosphate isomerase gene of Escherichia coli. Pichersky E, et al. Mol Gen Genet, 1984. PMID 6092857
    2. Replacing the (beta alpha)-unit 8 of E.coli TIM with its chicken homologue leads to a stable and active hybrid enzyme. Mainfroid V, et al. Protein Eng, 1993 Nov. PMID 8309937
    3. Triose-phosphate isomerase (TIM) of the psychrophilic bacterium Vibrio marinus. Kinetic and structural properties. Alvarez M, et al. J Biol Chem, 1998 Jan 23. PMID 9442062
    4. RNase G controls tpiA mRNA abundance in response to oxygen availability in Escherichia coli. Lee J, et al. J Microbiol, 2019 Oct. PMID 31571126
    5. Restoring a metabolic pathway. Richard JP. ACS Chem Biol, 2008 Oct 17. PMID 18928248

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNase G cleaves the 5' untranslated region of triosephosphate isomerase A (tpiA) mRNA, leading to destabilization of the mRNA in E. coli.
      Title: RNase G controls tpiA mRNA abundance in response to oxygen availability in Escherichia coli.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Protein identification with N and C-terminal sequence tags in proteome projects.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables triose-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables triose-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triose-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triose-phosphate isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glyceraldehyde-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    triose-phosphate isomerase
    NP_418354.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4110740..4111507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418354.1 triose-phosphate isomerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418354.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A485JNW8, A0A8S7TTD0, W1WXK6
      Conserved Domains (1) summary
      PRK00042
      Location:2 → 251
      tpiA; triosephosphate isomerase; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.