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    fpr flavodoxin/ferredoxin-NADP(+) reductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948414, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fpr
    Official Full Name
    flavodoxin/ferredoxin-NADP(+) reductase
    Primary source
    ECOCYC:EG10628
    Locus tag
    b3924
    See related
    ASAP:ABE-0012818
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3916; flxR; mvrA
    Summary
    The anaerobic nucleoside-triphosphate reductase activating system is composed of three enzymes and several compounds. [More information is available at EcoCyc: EG10628].
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    Genomic context

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    Sequence:
    NC_000913.3 (4113726..4114472, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF406 domain-containing protein YiiS Neighboring gene universal stress protein D Neighboring gene fructose-1,6-bisphosphatase 2 Neighboring gene glycerol kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ferredoxin, in conjunction with NADPH and ferredoxin-NADP reductase, transfers electrons to the IscS/IscU complex to promote iron-sulfur cluster assembly. Yan R, et al. Biochim Biophys Acta, 2015 Sep. PMID 25688831, Free PMC Article
    2. Interruption of the ferredoxin (flavodoxin) NADP+ oxidoreductase gene of Escherichia coli does not affect anaerobic growth but increases sensitivity to paraquat. Bianchi V, et al. J Bacteriol, 1995 Aug. PMID 7635836, Free PMC Article
    3. Functional complementation of the mvrA mutation of Escherichia coli by plant ferredoxin-NADP+ oxidoreductase. Krapp AR, et al. Arch Biochem Biophys, 1995 Feb 20. PMID 7872787
    4. The three-dimensional structure of flavodoxin reductase from Escherichia coli at 1.7 A resolution. Ingelman M, et al. J Mol Biol, 1997 Apr 25. PMID 9149148
    5. The mvrA locus of Escherichia coli does not encode a ferredoxin-NADP+ reductase. Rodriguez RE, et al. Microbiology (Reading), 1998 Sep. PMID 9782486

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A new catalytic mechanism of bacterial ferredoxin-NADP(+) reductases due to a particular NADP(+) binding mode.
      Title: A new catalytic mechanism of bacterial ferredoxin-NADP(+) reductases due to a particular NADP(+) binding mode.
    2. investigation of flavin-independent Fenton reaction system; NfnB and Fpr were purified and showed catalytic activities of ferric reduction; characterization of these enzymes and their involvement in the Fenton reaction and ferric reduction are presented
      Title: Escherichia coli ferredoxin-NADP+ reductase and oxygen-insensitive nitroreductase are capable of functioning as ferric reductase and of driving the Fenton reaction.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Escherichia coli ferredoxin NADP+ reductase: activation of E. coli anaerobic ribonucleotide reduction, cloning of the gene (fpr), and overexpression of the protein.
    4. G6PDH and FPR could act concertedly to deliver reducing equivalents from carbohydrates, via NADP(+), to the FPR acceptors ferredoxin and/or flavodoxin.
      Title: Glucose-6-phosphate dehydrogenase and ferredoxin-NADP(H) reductase contribute to damage repair during the soxRS response of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferredoxin-NADP+ reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferredoxin-NADP+ reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within iron-sulfur cluster assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to superoxide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to superoxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    flavodoxin/ferredoxin-NADP(+) reductase
    NP_418359.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4113726..4114472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418359.1 flavodoxin/ferredoxin-NADP(+) reductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418359.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7JX48
      Conserved Domains (1) summary
      PRK10926
      Location:1 → 248
      PRK10926; ferredoxin-NADP reductase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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