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    zapB cell division factor ZapB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948420, updated on 3-Dec-2024

    Summary

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    Official Symbol
    zapB
    Official Full Name
    cell division factor ZapB
    Primary source
    ECOCYC:EG11878
    Locus tag
    b3928
    See related
    ASAP:ABE-0012835
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3920; yiiU
    Summary
    ZapB forms filaments and binds FtsZ, presumably helping to form the initial Z-ring at the septum; septal localiztion of ZapB requires either FtsZ or ZipA; zapB mutants are elongated and have delayed cell division. [More information is available at EcoGene: EG11878]. The ZapB protein is a cell division factor that is required for proper Z ring formation. [More information is available at EcoCyc: EG11878].
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    Genomic context

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    Sequence:
    NC_000913.3 (4118515..4118760)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene glycerol kinase Neighboring gene glycerol facilitator Neighboring gene ribonuclease E inhibitor protein A Neighboring gene 1,4-dihydroxy-2-naphthoate octaprenyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactions among the early Escherichia coli divisome proteins revealed by bimolecular fluorescence complementation. Pazos M, et al. Environ Microbiol, 2013 Dec. PMID 23957637
    2. A MatP-divisome interaction coordinates chromosome segregation with cell division in E. coli. Espéli O, et al. EMBO J, 2012 May 11. PMID 22580828, Free PMC Article
    3. FtsZ-ZapA-ZapB interactome of Escherichia coli. Galli E, et al. J Bacteriol, 2012 Jan. PMID 22056926, Free PMC Article
    4. Spatial resolution of two bacterial cell division proteins: ZapA recruits ZapB to the inner face of the Z-ring. Galli E, et al. Mol Microbiol, 2010 Jun. PMID 20487275
    5. The N-succinyl-l,l-diaminopimelic acid desuccinylase DapE acts through ZapB to promote septum formation in Escherichia coli. Du S, et al. Mol Microbiol, 2017 Jul. PMID 28470834, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the replication terminus attaches to the divisome in a single segment along the perimeter of the cell in a MatP, ZapA and ZapB proteins-dependent manner.
      Title: The role of MatP, ZapA and ZapB in chromosomal organization and dynamics in Escherichia coli.
    2. These results suggest that the main function of ZapA and ZapB in vivo may not be to promote the association of individual protofilaments but to align FtsZ clusters that consist of multiple FtsZ protofilaments.
      Title: In vivo organization of the FtsZ-ring by ZapA and ZapB revealed by quantitative super-resolution microscopy.
    3. The authors propose a molecular model in which ZapA increases lateral interactions between FtsZ proto-filaments and ZapB mediates further stabilization of this interaction by cross-linking ZapA molecules bound to adjacent FtsZ proto-filaments.
      Title: Spatial resolution of two bacterial cell division proteins: ZapA recruits ZapB to the inner face of the Z-ring.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in FtsZ-dependent cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in FtsZ-dependent cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell septum assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in division septum assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division factor ZapB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4118515..4118760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418363.1 cell division factor ZapB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418363.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A192CEZ0, A0AA36L321
      Conserved Domains (1) summary
      PRK15422
      Location:3 → 81
      PRK15422; septal ring assembly protein ZapB; Provisional
    Nucleotide Protein
    Heading Accession and Version

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