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    menA 1,4-dihydroxy-2-naphthoate octaprenyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948418, updated on 17-Dec-2024

    Summary

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    Official Symbol
    menA
    Official Full Name
    1,4-dihydroxy-2-naphthoate octaprenyltransferase
    Primary source
    ECOCYC:EG11880
    Locus tag
    b3930
    See related
    ASAP:ABE-0012841
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3922; yiiW
    Summary
    1,4-dihydroxy-2-naphthoate octaprenyltransferase catalyzes the transfer of an octaprenyl side chain to DHNA, the reaction in menaquinone biosynthesis where the pathway becomes associated with the membrane . [More information is available at EcoCyc: EG11880].
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    Genomic context

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    Sequence:
    NC_000913.3 (4119423..4120349, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cell division factor ZapB Neighboring gene ribonuclease E inhibitor protein A Neighboring gene ATPase component of the HslVU protease Neighboring gene peptidase component of the HslVU protease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biosynthesis of bacterial menaquinones: the membrane-associated 1,4-dihydroxy-2-naphthoate octaprenyltransferase of Escherichia coli. Shineberg B, et al. Biochemistry, 1976 Jun 29. PMID 949474
    2. Regulation of RraA, a protein inhibitor of RNase E-mediated RNA decay. Zhao M, et al. J Bacteriol, 2006 May. PMID 16621818, Free PMC Article
    3. Biosynthesis of bacterial menaquinones. Menaquinone mutants of Escherichia coli. Young IG. Biochemistry, 1975 Jan 28. PMID 1091286
    4. Isolation and characterization of Escherichia coli mutants exhibiting altered response to thymol. Shapira R, et al. Microb Drug Resist, 2007 Fall. PMID 17949301
    5. Biosynthesis of menaquinone (vitamin K2) and ubiquinone (coenzyme Q): a perspective on enzymatic mechanisms. Meganathan R. Vitam Horm, 2001. PMID 11153266

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 1,4-dihydroxy-2-naphthoate polyprenyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1,4-dihydroxy-2-naphthoate polyprenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables prenyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ketone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in menaquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in menaquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within menaquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vitamin K biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1,4-dihydroxy-2-naphthoate octaprenyltransferase
    NP_418365.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4119423..4120349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418365.1 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418365.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FR25
      Conserved Domains (1) summary
      TIGR00751
      Location:17 → 300
      menA; 1,4-dihydroxy-2-naphthoate octaprenyltransferase
    Nucleotide Protein
    Heading Accession and Version

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