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    purD phosphoribosylamine--glycine ligase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948504, updated on 3-Dec-2024

    Summary

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    Official Symbol
    purD
    Official Full Name
    phosphoribosylamine--glycine ligase
    Primary source
    ECOCYC:EG10792
    Locus tag
    b4005
    See related
    ASAP:ABE-0013095
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    adth; adth(a); ECK3997
    Summary
    The purH and purD genes constitute a single operon and are coregulated in expression by purines as other purine genes are. [More information is available at EcoCyc: EG10792].
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    Genomic context

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    Sequence:
    NC_000913.3 (4204642..4205931, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene signaling pathway modulator ZraP Neighboring gene sensor histidine kinase ZraS Neighboring gene DNA-binding transcriptional activator ZraR Neighboring gene bifunctional AICAR transformylase/IMP cyclohydrolase Neighboring gene 16S ribosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glycinamide ribonucleotide synthetase from Escherichia coli: cloning, overproduction, sequencing, isolation, and characterization. Cheng YS, et al. Biochemistry, 1990 Jan 9. PMID 2182115
    2. Purine biosynthesis in Escherichia coli K12: structure and DNA sequence studies of the purHD locus. Flannigan KA, et al. Mol Microbiol, 1990 Mar. PMID 2192230
    3. [Phenotypic properties of Escherichia coli K-12 purine auxotrophs with disordered synthesis of guanine, xanthine and hypoxanthine phosphoribosyltransferases]. Brikun IA, et al. Genetika, 1981. PMID 6788651
    4. Fine mapping of the rrnE, purHD, and hydGH operons on the Escherichia coli chromosome. Peterson JW, et al. J Bacteriol, 1991 Jun. PMID 2045358, Free PMC Article
    5. The effect of DnaA protein levels and the rate of initiation at oriC on transcription originating in the ftsQ and ftsA genes: in vivo experiments. Masters M, et al. Mol Gen Genet, 1989 Apr. PMID 2546042

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylamine-glycine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosylamine-glycine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in purine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine nucleotide biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoribosylamine--glycine ligase
    NP_418433.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4204642..4205931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418433.1 phosphoribosylamine--glycine ligase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418433.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8H9SLX7
      Conserved Domains (1) summary
      PRK00885
      Location:1 → 426
      PRK00885; phosphoribosylamine--glycine ligase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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