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    mdtM multidrug efflux pump/bile salt:H(+) antiporter/Na(+):H(+) antiporter/K(+):H(+) antiporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948861, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mdtM
    Official Full Name
    multidrug efflux pump/bile salt:H(+) antiporter/Na(+):H(+) antiporter/K(+):H(+) antiporter
    Primary source
    ECOCYC:EG12576
    Locus tag
    b4337
    See related
    ASAP:ABE-0014221
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4328; yjiO
    Summary
    Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG12576]. The YjiO protein is, based on sequence similarity and hydropathy analysis, a member of the major facilitator superfamily (MFS) . [More information is available at EcoCyc: EG12576].
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    Genomic context

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    Sequence:
    NC_000913.3 (4567287..4568519, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative dehydratase subunit Neighboring gene DUF445 domain-containing protein YjiN Neighboring gene protein YtiE Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A single-component multidrug transporter of the major facilitator superfamily is part of a network that protects Escherichia coli from bile salt stress. Paul S, et al. Mol Microbiol, 2014 May. PMID 24684269, Free PMC Article
    2. Multidrug resistance protein MdtM adds to the repertoire of antiporters involved in alkaline pH homeostasis in Escherichia coli. Holdsworth SR, et al. BMC Microbiol, 2013 May 23. PMID 23701827, Free PMC Article
    3. Functional and biochemical characterisation of the Escherichia coli major facilitator superfamily multidrug transporter MdtM. Holdsworth SR, et al. Biochimie, 2012 Jun. PMID 22426385
    4. MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition. Edgar R, et al. J Bacteriol, 1997 Apr. PMID 9079913, Free PMC Article
    5. Influence of the yjiL-mdtM Gene Cluster on the Antibacterial Activity of Proline-Rich Antimicrobial Peptides Overcoming Escherichia coli Resistance Induced by the Missing SbmA Transporter System. Krizsan A, et al. Antimicrob Agents Chemother, 2015 Oct. PMID 26169420, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MdtM, a 410 amino acid residue protein that belongs to the large and ubiquitous major facilitator superfamily. [review]
      Title: Clamping down on drugs: the Escherichia coli multidrug efflux protein MdtM.
    2. The yjiL-mdtM gene cluster mediates the antibacterial activity of proline-rich antimicrobial peptides overcoming Escherichia coli resistance induced by the missing SbmA transporter system.
      Title: Influence of the yjiL-mdtM Gene Cluster on the Antibacterial Activity of Proline-Rich Antimicrobial Peptides Overcoming Escherichia coli Resistance Induced by the Missing SbmA Transporter System.
    3. MdtM, a single-component multidrug resistance transporter of the major facilitator superfamily, functions in bile salt resistance in Escherichia coli by catalysing secondary active transport of bile salts out of the cell cytoplasm.
      Title: A single-component multidrug transporter of the major facilitator superfamily is part of a network that protects Escherichia coli from bile salt stress.
    4. Taken together, the results support a role for MdtM in alkaline pH tolerance. MdtM can therefore be added to the currently limited list of antiporters known to function in pH homeostasis in the model organism E. coli.
      Title: Multidrug resistance protein MdtM adds to the repertoire of antiporters involved in alkaline pH homeostasis in Escherichia coli.
    5. Purified MdtM is monomeric and stable in dodecyl-beta-D-maltopyranoside solution and binds chloramphenicol with nanomolar affinity in the same detergent.
      Title: Functional and biochemical characterisation of the Escherichia coli major facilitator superfamily multidrug transporter MdtM.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bile acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables bile acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables potassium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in bile acid and bile salt transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cellular pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    multidrug efflux pump/bile salt:H(+) antiporter/Na(+):H(+) antiporter/K(+):H(+) antiporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4567287..4568519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418757.1 multidrug efflux pump/bile salt:H(+) antiporter/Na(+):H(+) antiporter/K(+):H(+) antiporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418757.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376X7E5
      Conserved Domains (1) summary
      PRK15403
      Location:1 → 410
      PRK15403; multidrug efflux MFS transporter MdtM
    Nucleotide Protein
    Heading Accession and Version

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