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    arcA DNA-binding transcriptional dual regulator ArcA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948874, updated on 3-Dec-2024

    Summary

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    Official Symbol
    arcA
    Official Full Name
    DNA-binding transcriptional dual regulator ArcA
    Primary source
    ECOCYC:EG10061
    Locus tag
    b4401
    See related
    ASAP:ABE-0014434
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cpxC; dye; ECK4393; fexA; msp; seg; sfrA
    Summary
    This is a dual transcriptional regulator of aerobic respiration control. [More information is available at EcoCyc: EG10061].
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    Genomic context

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    Sequence:
    NC_000913.3 (4639590..4640306, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional regulator CreB Neighboring gene sensory histidine kinase CreC Neighboring gene putative inner membrane protein CreD Neighboring gene uncharacterized protein YjjY Neighboring gene protein YtjE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the dye gene product, mutational loss of which alters envelope protein composition and also affects sex factor F expression in Escherichia coli K-12. Buxton RS, et al. Mol Gen Genet, 1984. PMID 6328216
    2. Structural analysis and solution studies of the activated regulatory domain of the response regulator ArcA: a symmetric dimer mediated by the alpha4-beta5-alpha5 face. Toro-Roman A, et al. J Mol Biol, 2005 May 27. PMID 15876365, Free PMC Article
    3. ArcA redox mutants as a source of reduced bioproducts. Pettinari MJ, et al. J Mol Microbiol Biotechnol, 2008. PMID 18349549
    4. Cooperative Function of TraJ and ArcA in Regulating the F Plasmid tra Operon. Lu J, et al. J Bacteriol, 2019 Jan 1. PMID 30322855, Free PMC Article
    5. ArcA overexpression induces fermentation and results in enhanced growth rates of E. coli. Basan M, et al. Sci Rep, 2017 Sep 19. PMID 28928483, Free PMC Article

    See all (124) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of ArcA in the regulation of antibiotic sensitivity in avian pathogenic Escherichia coli.
      Title: Role of ArcA in the regulation of antibiotic sensitivity in avian pathogenic Escherichia coli.
    2. Theoretical study of ArcB and its dimerization, interaction with anaerobic metabolites, and activation of ArcA.
      Title: Theoretical study of ArcB and its dimerization, interaction with anaerobic metabolites, and activation of ArcA.
    3. The results suggest that deletion of arcA, iclR, and tdcC could efficiently increase l-threonine production in E. coli.
      Title: Deletion of arcA, iclR, and tdcC in Escherichia coli to improve l-threonine production.
    4. These data reveal the cooperativity of TraJ and ArcA during F plasmid PY promoter activation and provide insights into the regulatory circuit controlling F-family plasmid-mediated bacterial conjugation.
      Title: Cooperative Function of TraJ and ArcA in Regulating the F Plasmid tra Operon.
    5. Study reports the in-situ structure of the E. coli AcrAB-TolC multidrug efflux pump obtained by electron cryo-tomography. The fully assembled efflux pump is observed in a closed state under conditions of antibiotic challenge and in an open state in the presence of AcrB inhibitor. Also study observed intermediate AcrAB complexes without TolC and discover that AcrA contacts the peptidoglycan layer of the periplasm.
      Title: In situ structure and assembly of the multidrug efflux pump AcrAB-TolC.
    6. increased lag phases of ArcA overexpression strains, respiratory energy metabolism may be related to a general preparatory response, observed for decreasing growth rates, but with limited advantages for maximizing steady-state growth rate.
      Title: ArcA overexpression induces fermentation and results in enhanced growth rates of E. coli.
    7. The authors report the near-atomic resolution cryoEM structures of the Escherichia coli AcrAB-TolC multidrug efflux pump in resting and drug transport states, revealing a quaternary structural switch that allosterically couples and synchronizes initial ligand binding with channel opening.
      Title: An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump.
    8. The combined results indicate that ArcA controls metabolism, chemotaxis, and motility contributing to the pathogenicity of Avian pathogenic Escherichia coli
      Title: ArcA Controls Metabolism, Chemotaxis, and Motility Contributing to the Pathogenicity of Avian Pathogenic Escherichia coli.
    9. We propose that this plasticity in ArcA binding site architecture provides both an efficient means of encoding binding sites for ArcA, sigma(70)-RNAP and perhaps other transcription factors
      Title: The bacterial response regulator ArcA uses a diverse binding site architecture to regulate carbon oxidation globally.
    10. Interactions between TolC and AcrAB are highly dynamic and only a small fraction of TolC is utilized to support efflux activities.
      Title: On the role of TolC in multidrug efflux: the function and assembly of AcrAB-TolC tolerate significant depletion of intracellular TolC protein.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphorelay response regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorelay response regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorelay signal transduction system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-DNA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator ArcA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4639590..4640306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418818.1 DNA-binding transcriptional dual regulator ArcA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418818.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AAK3
      Conserved Domains (1) summary
      PRK11173
      Location:1 → 237
      PRK11173; two-component response regulator; Provisional
    Nucleotide Protein
    Heading Accession and Version

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