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    ftsQ cell division protein FtsQ [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944823, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ftsQ
    Official Full Name
    cell division protein FtsQ
    Primary source
    ECOCYC:EG10342
    Locus tag
    b0093
    See related
    ASAP:ABE-0000329
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0094
    Summary
    Overexpression causes filamentous biofilm formation. [More information is available at EcoGene: EG10342]. FtsQ is an essential cell division protein that is required throughout the process of septum formation; the protein is present in very small amounts of approximately 22 molecules per cell . [More information is available at EcoCyc: EG10342].
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    Genomic context

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    Sequence:
    NC_000913.3 (103155..103985)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidoglycan glycosyltransferase FtsW Neighboring gene N-acetylglucosaminyl transferase Neighboring gene UDP-N-acetylmuramate--L-alanine ligase Neighboring gene D-alanine--D-alanine ligase B Neighboring gene cell division protein FtsA Neighboring gene cell division protein FtsZ Neighboring gene UDP-3-O-acyl-N-acetylglucosamine deacetylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An amino-proximal domain required for the localization of FtsQ in the cytoplasmic membrane, and for its biological function in Escherichia coli. Dopazo A, et al. Mol Microbiol, 1992 Mar. PMID 1574000
    2. Analysis of ftsQ mutant alleles in Escherichia coli: complementation, septal localization, and recruitment of downstream cell division proteins. Chen JC, et al. J Bacteriol, 2002 Feb. PMID 11790739, Free PMC Article
    3. Localization of cell division protein FtsQ by immunofluorescence microscopy in dividing and nondividing cells of Escherichia coli. Buddelmeijer N, et al. J Bacteriol, 1998 Dec. PMID 9829918, Free PMC Article
    4. The ftsQ1p gearbox promoter of Escherichia coli is a major sigma S-dependent promoter in the ddlB-ftsA region. Ballesteros M, et al. Mol Microbiol, 1998 Oct. PMID 9791185
    5. Genetic reporter system for positioning of proteins at the bacterial pole. Fixen KR, et al. mBio, 2012. PMID 22375072, Free PMC Article

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation.
      Title: The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation.
    2. Crystal structure of FtsB bound to the beta domain of FtsQ shows that only residues 64 to 87 of FtsB interact with FtsQ.
      Title: Structural Analysis of the Interaction between the Bacterial Cell Division Proteins FtsQ and FtsB.
    3. results support a model in which FtsL, along with its partners FtsB and FtsQ, function as part of a sensing mechanism that promotes the onset of cell wall remodeling processes.
      Title: A role for the FtsQLB complex in cytokinetic ring activation revealed by an ftsL allele that accelerates division.
    4. results suggest that the FtsQ interaction with FtsN, although not strictly essential for the division process, at least in some conditions, plays a role in the proper formation or stability of the division machinery
      Title: Essential and non-essential interactions in interactome networks: the Escherichia coli division proteins FtsQ-FtsN interaction.
    5. show that the conserved cell division protein FtsQ is required for localization of IcsA and other autotransporters to the pole.
      Title: Genetic reporter system for positioning of proteins at the bacterial pole.
    6. A structural model was developed for the periplasmic part of the FtsB/FtsL/FtsQ complex.
      Title: A model for the Escherichia coli FtsB/FtsL/FtsQ cell division complex.
    7. Results allow the identification of FtsQ residues involved in the interaction with other partner proteins and the determination of the biological significance of these interactions.
      Title: FtsQ interaction mutants: a way to identify new antibacterial targets.
    8. Study find that, as with FtsB, the C terminus of FtsL is required for the interaction of FtsQ with the FtsB/FtsL subcomplex while the cytoplasmic domain of FtsL is involved in recruitment of the downstream division proteins.
      Title: Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex.
    9. Our results indicate that the FtsQ TMS plays a role in FtsQ localization to the division site.
      Title: Contribution of the FtsQ transmembrane segment to localization to the cell division site.
    10. FtsQ is associated in a hierarchical set of protein complexes and its assembly can occur independently of 'upstream' proteins.
      Title: Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in FtsZ-dependent cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within FtsZ-dependent cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in FtsZ-dependent cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell septum assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within division septum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in division septum assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FtsQBL complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell division site IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell division site NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of divisome complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division protein FtsQ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      103155..103985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414635.1 cell division protein FtsQ [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414635.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377DF54
      Conserved Domains (1) summary
      PRK10775
      Location:1 → 264
      PRK10775; cell division protein FtsQ; Provisional
    Nucleotide Protein
    Heading Accession and Version

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