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    dapD tetrahydrodipicolinate succinylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944862, updated on 3-Dec-2024

    Summary

    Official Symbol
    dapD
    Official Full Name
    tetrahydrodipicolinate succinylase
    Primary source
    ECOCYC:EG10207
    Locus tag
    b0166
    See related
    ASAP:ABE-0000565
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0164; ssa
    Summary
    A dapD mutant is not in the Keio collection; DAP auxotrophs require added DAP to grow and since no DAP was added during mutant construction, no auxotrophic mutants were recovered; dapD is not an essential gene (Baba, 2006). [More information is available at EcoGene: EG10207]. Tetrahydrodipicolinate succinylase catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate, and is a key enzyme in the Escherichia coli lysine biosynthetic pathway. [More information is available at EcoCyc: EG10207].
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    Genomic context

    Sequence:
    NC_000913.3 (185123..185947, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF3461 domain-containing protein YaeH Neighboring gene phosphodiesterase YaeI Neighboring gene protein-PII uridylyltransferase/uridylyl-removing enzyme Neighboring gene methionine aminopeptidase

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    involved_in diaminopimelate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in diaminopimelate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within diaminopimelate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lysine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lysine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lysine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lysine biosynthetic process via diaminopimelate IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tetrahydrodipicolinate succinylase
    NP_414708.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      185123..185947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414708.1 tetrahydrodipicolinate succinylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414708.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1PIE7
      Conserved Domains (1) summary
      PRK11830
      Location:1271
      dapD; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional