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    rclA cupric reductase RclA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946092, updated on 17-Dec-2024

    Summary

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    Official Symbol
    rclA
    Official Full Name
    cupric reductase RclA
    Primary source
    ECOCYC:G6174
    Locus tag
    b0304
    See related
    ASAP:ABE-0001048
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0303; ykgC
    Summary
    AFMB Structural Genomics target Number 2 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG13580].
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    Genomic context

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    Sequence:
    NC_000913.3 (318676..320001, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF417 domain-containing inner membrane protein RclC Neighboring gene DUF1471 domain-containing protein RclB Neighboring gene DNA-binding transcriptional activator RclR Neighboring gene putative lactate utilization oxidoreductase YkgE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Escherichia coli RclA is a highly active hypothiocyanite reductase. Meredith JD, et al. Proc Natl Acad Sci U S A, 2022 Jul 26. PMID 35867824, Free PMC Article
    2. The Cu(II) Reductase RclA Protects Escherichia coli against the Combination of Hypochlorous Acid and Intracellular Copper. Derke RM, et al. mBio, 2020 Sep 29. PMID 32994322, Free PMC Article
    3. Structure and function of the hypochlorous acid-induced flavoprotein RclA from Escherichia coli. Baek Y, et al. J Biol Chem, 2020 Mar 6. PMID 31988242, Free PMC Article
    4. Flavoprotein-Mediated Tellurite Reduction: Structural Basis and Applications to the Synthesis of Tellurium-Containing Nanostructures. Arenas-Salinas M, et al. Front Microbiol, 2016. PMID 27507969, Free PMC Article
    5. Flavoprotein disulfide reductases: advances in chemistry and function. Argyrou A, et al. Prog Nucleic Acid Res Mol Biol, 2004. PMID 15210329

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Escherichia coli RclA is a highly active hypothiocyanite reductase.
      Title: Escherichia coli RclA is a highly active hypothiocyanite reductase.
    2. The Cu(II) Reductase RclA Protects Escherichia coli against the Combination of Hypochlorous Acid and Intracellular Copper.
      Title: The Cu(II) Reductase RclA Protects Escherichia coli against the Combination of Hypochlorous Acid and Intracellular Copper.
    3. Structure and function of the hypochlorous acid-induced flavoprotein RclA from Escherichia coli.
      Title: Structure and function of the hypochlorous acid-induced flavoprotein RclA from Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NAD(P)H dehydrogenase (quinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cupric reductase (NADH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to hypochlorite IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hypochlorite IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cupric reductase RclA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      318676..320001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414838.2 cupric reductase RclA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414838.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1MMC3
      Conserved Domains (1) summary
      PRK08010
      Location:1 → 441
      PRK08010; pyridine nucleotide-disulfide oxidoreductase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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