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    recR recombination mediator protein RecR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945100, updated on 3-Dec-2024

    Summary

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    Official Symbol
    recR
    Official Full Name
    recombination mediator protein RecR
    Primary source
    ECOCYC:EG10834
    Locus tag
    b0472
    See related
    ASAP:ABE-0001638
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0466
    Summary
    [More information is available at EcoCyc: EG10834].
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    Genomic context

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    Sequence:
    NC_000913.3 (494405..495010)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene adenine phosphoribosyltransferase Neighboring gene DNA polymerase III subunit gamma;DNA polymerase III subunit tau Neighboring gene putative nucleoid-associated protein YbaB Neighboring gene chaperone protein HtpG Neighboring gene adenylate kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the recR locus of Escherichia coli K-12 and analysis of its role in recombination and DNA repair. Mahdi AA, et al. Mol Gen Genet, 1989 Apr. PMID 2664459
    2. RecF protein targeting to postreplication (daughter strand) gaps I: DNA binding by RecF and RecFR. Henry C, et al. Nucleic Acids Res, 2023 Jun 23. PMID 37125642, Free PMC Article
    3. Sequence and expression of the Escherichia coli recR locus. Yeung T, et al. J Bacteriol, 1990 Oct. PMID 1698765, Free PMC Article
    4. The recR locus of Escherichia coli K-12: molecular cloning, DNA sequencing and identification of the gene product. Mahdi AA, et al. Nucleic Acids Res, 1989 Sep 12. PMID 2674903, Free PMC Article
    5. An interaction between the Escherichia coli RecF and RecR proteins dependent on ATP and double-stranded DNA. Webb BL, et al. J Biol Chem, 1995 Dec 29. PMID 8537414

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RecF protein targeting to postreplication (daughter strand) gaps I: DNA binding by RecF and RecFR.
      Title: RecF protein targeting to postreplication (daughter strand) gaps I: DNA binding by RecF and RecFR.
    2. Allosteric effects of SSB C-terminal tail on assembly of E. coli RecOR proteins.
      Title: Allosteric effects of SSB C-terminal tail on assembly of E. coli RecOR proteins.
    3. RecF foci frequently colocalize with replisome markers. In response to DNA damage, colocalization increases and RecF dimerizes. The majority of RecF foci are dependent on RecR. Conversely, RecO foci occur infrequently, rarely colocalize with replisomes or RecF and are largely independent of RecR.
      Title: RecFOR epistasis group: RecF and RecO have distinct localizations and functions in Escherichia coli.
    4. RecOR, and possibly other SSB-interacting proteins, function(s) in part to alter long-range, macroscopic interactions between or throughout nucleoprotein complexes by microscopically altering wrapping and bridging distant sites.
      Title: Imaging and energetics of single SSB-ssDNA molecules reveal intramolecular condensation and insight into RecOR function.
    5. Data show that UvrD and UvrD252 counteract RecQ, RecJ, and RecFOR at forks blocked in the rep mutant of Escherichia coli.
      Title: UvrD and UvrD252 counteract RecQ, RecJ, and RecFOR in a rep mutant of Escherichia coli.
    6. When an SSB variant that lacks the C-terminal 8 amino acids is used, the capacity of RecOR to facilitate RecA loading onto the ssDNA is largely abolished
      Title: SSB protein limits RecOR binding onto single-stranded DNA.
    7. All three recombination mediator proteins RecFOR are needed to build a functionally competent RecA filament that supports efficient Pol V-mediated translesion synthesis in the presence of ssDNA-binding protein.
      Title: RecFOR proteins are essential for Pol V-mediated translesion synthesis and mutagenesis.
    8. genetic analysis of recombination in a recB recD double mutant was performed; results show that conjugational recombination and DNA repair in this mutant are highly dependent on recJ, partially dependent on recFOR, and independent of recQ
      Title: Effects of recJ, recQ, and recFOR mutations on recombination in nuclease-deficient recB recD double mutants of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA synthesis involved in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in recombinational repair EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in recombinational repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in recombinational repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to UV EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    recombination mediator protein RecR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      494405..495010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415005.1 recombination mediator protein RecR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415005.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7D7PGL0
      Conserved Domains (1) summary
      PRK00076
      Location:2 → 199
      recR; recombination protein RecR; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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