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    entE 2,3-dihydroxybenzoate-AMP ligase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947426, updated on 3-Dec-2024

    Summary

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    Official Symbol
    entE
    Official Full Name
    2,3-dihydroxybenzoate-AMP ligase
    Primary source
    ECOCYC:EG10263
    Locus tag
    b0594
    See related
    ASAP:ABE-0002049
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0587
    Summary
    Recent gel filtration data suggest that EntE may be a monomer not a dimer. [More information is available at EcoCyc: EG10263].
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    Genomic context

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    Sequence:
    NC_000913.3 (626070..627680)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ferric enterobactin ABC transporter periplasmic binding protein Neighboring gene isochorismate synthase EntC Neighboring gene enterobactin synthase component B Neighboring gene 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase Neighboring gene proofreading thioesterase in enterobactin biosynthesis

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Studies on the enzymatic synthesis of enterochelin in Escherichia coli K-12. Four polypeptides involved in the conversion of 2,3-dihydroxybenzoate to enterochelin. Greenwood KT, et al. Biochim Biophys Acta, 1976 Dec 1. PMID 136989
    2. Enterobactin synthetase-catalyzed formation of P(1),P(3)-diadenosine-5'-tetraphosphate. Sikora AL, et al. Biochemistry, 2009 Nov 24. PMID 19852513, Free PMC Article
    3. Aryl acid adenylating enzymes involved in siderophore biosynthesis: fluorescence polarization assay, ligand specificity, and discovery of non-nucleoside inhibitors via high-throughput screening. Neres J, et al. Biochemistry, 2008 Nov 11. PMID 18928302, Free PMC Article
    4. Biosynthesis of enterochelin in Escherichia coli K-12: separation of the polypeptides coded for by the entD, E, F and G genes. Woodrow GC, et al. Biochim Biophys Acta, 1979 Jan 4. PMID 216414
    5. Subcloning, expression, and purification of the enterobactin biosynthetic enzyme 2,3-dihydroxybenzoate-AMP ligase: demonstration of enzyme-bound (2,3-dihydroxybenzoyl)adenylate product. Rusnak F, et al. Biochemistry, 1989 Aug 22. PMID 2531000

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional analysis showed that the EntB-EntE interaction was surprisingly tolerant of a number of point mutations on the surface of EntB and EntE.
      Title: Structure of the EntB multidomain nonribosomal peptide synthetase and functional analysis of its interaction with the EntE adenylation domain.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2,3-dihydroxybenzoate--[aryl-carrier protein] ligase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2,3-dihydroxybenzoate--[aryl-carrier protein] ligase IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2,3-dihydroxybenzoate-serine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2,3-dihydroxybenzoate-serine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity, forming carbon-sulfur bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in enterobactin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in enterobactin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within enterobactin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siderophore biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2,3-dihydroxybenzoate-AMP ligase
    NP_415126.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      626070..627680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415126.1 2,3-dihydroxybenzoate-AMP ligase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415126.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EGP4
      Conserved Domains (1) summary
      PRK10946
      Location:1 → 536
      entE; (2,3-dihydroxybenzoyl)adenylate synthase
    Nucleotide Protein
    Heading Accession and Version

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