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    zapC cell division protein ZapC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945552, updated on 3-Dec-2024

    Summary

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    Official Symbol
    zapC
    Official Full Name
    cell division protein ZapC
    Primary source
    ECOCYC:G6486
    Locus tag
    b0946
    See related
    ASAP:ABE-0003204
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0937; ycbW
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    Genomic context

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    Sequence:
    NC_000913.3 (1005952..1006494)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative fimbrial protein YcbV Neighboring gene putative fimbrial chaperone YcbF Neighboring gene dihydroorotate dehydrogenase, type 2 Neighboring gene 6-N-hydroxylaminopurine resistance protein Neighboring gene fused 23S rRNA m(2)G2445 methyltransferase and 23S rRNA m(7)G2069 methyltransferase Neighboring gene ATP-binding protein Uup

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of ZapC, a stabilizer of the FtsZ ring in Escherichia coli. Durand-Heredia JM, et al. J Bacteriol, 2011 Mar. PMID 21216995, Free PMC Article
    2. Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC. Schumacher MA, et al. J Biol Chem, 2016 Jan 29. PMID 26655719, Free PMC Article
    3. Crystal structure of the Z-ring associated cell division protein ZapC from Escherichia coli. Ortiz C, et al. FEBS Lett, 2015 Dec 21. PMID 26619764, Free PMC Article
    4. Identification of Escherichia coli ZapC (YcbW) as a component of the division apparatus that binds and bundles FtsZ polymers. Hale CA, et al. J Bacteriol, 2011 Mar. PMID 21216997, Free PMC Article
    5. Interaction network containing conserved and essential protein complexes in Escherichia coli. Butland G, et al. Nature, 2005 Feb 3. PMID 15690043

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors report the identification of an FtsZ stabilizer, ZapC (Z-associated protein C), in a protein localization screen conducted with E. coli.
      Title: Identification and characterization of ZapC, a stabilizer of the FtsZ ring in Escherichia coli.
    2. ZapC binds the large FtsZ globular core rather than C-terminal tail, and the presence of two adjacent pockets suggests possible mechanisms for ZapC-mediated FtsZ bundling
      Title: Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC.
    3. Binding of YcbW (ZapC) to FtsZ promotes lateral interactions between FtsZ polymers and suppresses FtsZ GTPase activity.
      Title: Identification of Escherichia coli ZapC (YcbW) as a component of the division apparatus that binds and bundles FtsZ polymers.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within FtsZ-dependent cytokinesis EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in FtsZ-dependent cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell septum assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in division septum assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cell division protein ZapC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1005952..1006494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415466.4 cell division protein ZapC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415466.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7NQX7, W1WDG5
      Conserved Domains (1) summary
      pfam07126
      Location:2 → 167
      ZapC; Cell-division protein ZapC
    Nucleotide Protein
    Heading Accession and Version

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