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    dinI DNA damage-inducible protein I [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945022, updated on 17-Dec-2024

    Summary

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    Official Symbol
    dinI
    Official Full Name
    DNA damage-inducible protein I
    Primary source
    ECOCYC:G6558
    Locus tag
    b1061
    See related
    ASAP:ABE-0003599
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1046
    Summary
    DinI inhibits RecA co-protease activity of UmuD, but not LexA. [More information is available at EcoGene: EG12670]. The dinI gene was first identified as a chromosomal locus containing a high affinity operator for the LexA repressor . [More information is available at EcoCyc: G6558].
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    Genomic context

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    Sequence:
    NC_000913.3 (1121242..1121487, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene N-methyl-L-tryptophan oxidase Neighboring gene regulator of biofilm formation Neighboring gene dihydroorotase Neighboring gene putative lipid-binding lipoprotein YceB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein mimicry of DNA and pathway regulation. Putnam CD, et al. DNA Repair (Amst), 2005 Dec 8. PMID 16226493
    2. A model for the abrogation of the SOS response by an SOS protein: a negatively charged helix in DinI mimics DNA in its interaction with RecA. Voloshin ON, et al. Genes Dev, 2001 Feb 15. PMID 11230150, Free PMC Article
    3. Two modes of binding of DinI to RecA filament provide a new insight into the regulation of SOS response by DinI protein. Galkin VE, et al. J Mol Biol, 2011 May 20. PMID 21458462, Free PMC Article
    4. DinI and RecX modulate RecA-DNA structures in Escherichia coli K-12. Renzette N, et al. Mol Microbiol, 2007 Jan. PMID 17163974
    5. The DinI protein stabilizes RecA protein filaments. Lusetti SL, et al. J Biol Chem, 2004 Jul 16. PMID 15138263

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DinI either binds to the C-terminus of a RecA protomer or DinI resides deeply in the groove of the RecA filament, with its negatively charged C-terminal helix proximal to the L2 loop of RecA.
      Title: Two modes of binding of DinI to RecA filament provide a new insight into the regulation of SOS response by DinI protein.
    2. DinI and RecX are competing modulators of RecA function
      Title: The DinI and RecX proteins are competing modulators of RecA function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in SOS response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within SOS response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in SOS response IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA damage-inducible protein I

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1121242..1121487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415579.1 DNA damage-inducible protein I [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415579.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3IAL6, A0A1X3J436, A0A1X3JIT0, A0AA36KWT0, Q1RD96
      Conserved Domains (1) summary
      PRK10597
      Location:1 → 81
      PRK10597; DNA damage-inducible protein I; Provisional
    Nucleotide Protein
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