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    lsrF 3-hydroxy-2,4-pentadione 5-phosphate thiolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946071, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lsrF
    Official Full Name
    3-hydroxy-2,4-pentadione 5-phosphate thiolase
    Primary source
    ECOCYC:G6804
    Locus tag
    b1517
    See related
    ASAP:ABE-0005065
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1510; yneB
    Summary
    LsrF is part of an operon for autoinducer-2 (AI-2) uptake regulated by LsrR and LuxS, through AI-2. [More information is available at EcoGene: EG13810].
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    Genomic context

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    Sequence:
    NC_000913.3 (1606100..1606975)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Autoinducer-2 ABC transporter membrane subunit LsrC Neighboring gene Autoinducer-2 ABC transporter membrane subunit LsrD Neighboring gene Autoinducer-2 ABC transporter periplasmic binding protein Neighboring gene (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase Neighboring gene trans-aconitate 2-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LsrF, a coenzyme A-dependent thiolase, catalyzes the terminal step in processing the quorum sensing signal autoinducer-2. Marques JC, et al. Proc Natl Acad Sci U S A, 2014 Sep 30. PMID 25225400, Free PMC Article
    2. The crystal structure of the Escherichia coli autoinducer-2 processing protein LsrF. Diaz Z, et al. PLoS One, 2009 Aug 28. PMID 19714241, Free PMC Article
    3. Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. Xavier KB, et al. ACS Chem Biol, 2007 Feb 20. PMID 17274596
    4. Lsr-mediated transport and processing of AI-2 in Salmonella typhimurium. Taga ME, et al. Mol Microbiol, 2003 Nov. PMID 14622426
    5. The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. Taga ME, et al. Mol Microbiol, 2001 Nov. PMID 11722742

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables acyltransferase activity, transferring groups other than amino-acyl groups IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose-bisphosphate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3-hydroxy-2,4-pentadione 5-phosphate thiolase
    NP_416034.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1606100..1606975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416034.1 3-hydroxy-2,4-pentadione 5-phosphate thiolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416034.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8H9XL45
      Conserved Domains (1) summary
      PRK08227
      Location:28 → 291
      PRK08227; 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase
    Nucleotide Protein
    Heading Accession and Version

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