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    dgcZ diguanylate cyclase DgcZ [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946075, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dgcZ
    Official Full Name
    diguanylate cyclase DgcZ
    Primary source
    ECOCYC:EG11643
    Locus tag
    b1535
    See related
    ASAP:ABE-0005123
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1528; ydeG; ydeH
    Summary
    YdeH mRNA is translationally repressed by CsrA (Jonas, 2008). ydeH overexpression causes a 20-fold increase in di-c-GMP and represses motility, but a ydeH mutant has little effect (Jonas, 2008). [More information is available at EcoGene: EG11643]. YdeH is a diguanylate cyclase that regulates motility; the effect on motility is probably mediated by the second messenger c-di-GMP . [More information is available at EcoCyc: EG11643].
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    Genomic context

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    Sequence:
    NC_000913.3 (1622960..1623850, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene small protein MgtS Neighboring gene protein MgtT Neighboring gene ncRNA Neighboring gene BOF family protein YdeI Neighboring gene PF02464 family protein YdeJ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. More than Enzymes That Make or Break Cyclic Di-GMP-Local Signaling in the Interactome of GGDEF/EAL Domain Proteins of Escherichia coli. Sarenko O, et al. mBio, 2017 Oct 10. PMID 29018125, Free PMC Article
    2. Evidence for Escherichia coli Diguanylate Cyclase DgcZ Interlinking Surface Sensing and Adhesion via Multiple Regulatory Routes. Lacanna E, et al. J Bacteriol, 2016 Sep 15. PMID 27402625, Free PMC Article
    3. Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress. Boehm A, et al. Mol Microbiol, 2009 Jun. PMID 19460094
    4. The RNA binding protein CsrA controls cyclic di-GMP metabolism by directly regulating the expression of GGDEF proteins. Jonas K, et al. Mol Microbiol, 2008 Oct. PMID 18713317, Free PMC Article
    5. Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli. Cohen SP, et al. J Bacteriol, 1993 Mar. PMID 8383113, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diguanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diguanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diguanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion involved in single-species biofilm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell adhesion involved in single-species biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of bacterial-type flagellum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of bacterial-type flagellum-dependent cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of single-species biofilm formation on inanimate substrate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    diguanylate cyclase DgcZ
    NP_416052.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1622960..1623850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416052.1 diguanylate cyclase DgcZ [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416052.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376TFL3
      Conserved Domains (1) summary
      PRK09894
      Location:1 → 296
      PRK09894; diguanylate cyclase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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