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    cedA cell division modulator [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946235, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cedA
    Official Full Name
    cell division modulator
    Primary source
    ECOCYC:G6936
    Locus tag
    b1731
    See related
    ASAP:ABE-0005776
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1729; ydjP
    Summary
    Second ATG is chosen because of S.t. alignment and RBS. [More information is available at EcoGene: EG13992]. CedA appears to be involved in the regulation of cell division in a wild-type or dnaA mutant strain . [More information is available at EcoCyc: G6936].
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    Genomic context

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    Sequence:
    NC_000913.3 (1813421..1813663, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cystine/sulfocysteine:cation symporter Neighboring gene protein YdjO Neighboring gene catalase HPII Neighboring gene chitooligosaccharide monodeacetylase ChbG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of functional interactome of a key cell division regulatory protein CedA of E.coli. Sharma P, et al. Int J Biol Macromol, 2018 Jan. PMID 28818726
    2. Functional analysis of CedA based on its structure: residues important in binding of DNA and RNA polymerase and in the cell division regulation. Abe Y, et al. J Biochem, 2016 Feb. PMID 26400504, Free PMC Article
    3. Solution structure and interactions of the Escherichia coli cell division activator protein CedA. Chen HA, et al. Biochemistry, 2005 May 10. PMID 15865419
    4. CedA is a novel Escherichia coli protein that activates the cell division inhibited by chromosomal DNA over-replication. Katayama T, et al. Mol Microbiol, 1997 Nov. PMID 9427399
    5. Large-scale identification of protein-protein interaction of Escherichia coli K-12. Arifuzzaman M, et al. Genome Res, 2006 May. PMID 16606699, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Based on CedA binding proteins identified, we hypothesize that CedA plays a crucial and multifaceted role in cell cycle regulation and specific pathways in which CedA participates may include transcription and energy metabolism. However, further validation through in-vitro and in-vivo experiments is necessary.
      Title: Identification of functional interactome of a key cell division regulatory protein CedA of E.coli.
    2. CedA may be involved in the reactivation of DnaA suffering inactivation. In particular, Glu32 in CedA is an essential residue for cell division reactivation and may interact with the DnaA molecule, directly or indirectly.
      Title: Functional analysis of CedA based on its structure: residues important in binding of DNA and RNA polymerase and in the cell division regulation.
    3. CedA shows structural similarity to a family of DNA-binding proteins which interact with double-stranded DNA via a three-stranded beta-sheet, suggesting that CedA may be a DNA-binding protein.
      Title: Solution structure and interactions of the Escherichia coli cell division activator protein CedA.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division modulator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1813421..1813663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416245.2 cell division modulator [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416245.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2H4TZC1, A0A836NBV5, A0AAP7TXN8
      Conserved Domains (1) summary
      PRK10113
      Location:1 → 80
      PRK10113; cell division activator CedA
    Nucleotide Protein
    Heading Accession and Version

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