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    ftnA ferritin iron storage protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946410, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ftnA
    Official Full Name
    ferritin iron storage protein
    Primary source
    ECOCYC:EG10921
    Locus tag
    b1905
    See related
    ASAP:ABE-0006342
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1904; ftn; gen-165; rsgA
    Summary
    FtnA helps re-assemble iron-sulfur clusters after oxidative damage (Bitoun, 2008). [More information is available at EcoGene: EG10921]. ftnA encodes the iron-storage protein ferritin, which is similar to human ferritin H . [More information is available at EcoCyc: EG10921].
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    Genomic context

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    Sequence:
    NC_000913.3 (1988716..1989213)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein AzuC Neighboring gene lipoprotein YecR Neighboring gene DUF2492 domain-containing protein YecH Neighboring gene tyrosine:H(+) symporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functionality of the three-site ferroxidase center of Escherichia coli bacterial ferritin (EcFtnA). Bou-Abdallah F, et al. Biochemistry, 2014 Jan 28. PMID 24380371, Free PMC Article
    2. Structural Basis of Novel Iron-Uptake Route and Reaction Intermediates in Ferritins from Gram-Negative Bacteria. Kim S, et al. J Mol Biol, 2016 Dec 4. PMID 27777002
    3. Cloning and sequencing of an Escherichia coli K12 gene which encodes a polypeptide having similarity to the human ferritin H subunit. Izuhara M, et al. Mol Gen Genet, 1991 Mar. PMID 2017145
    4. Direct observation of the iron binding sites in a ferritin. Hempstead PD, et al. FEBS Lett, 1994 Aug 22. PMID 8070575
    5. How the presence of three iron binding sites affects the iron storage function of the ferritin (EcFtnA) of Escherichia coli. Treffry A, et al. FEBS Lett, 1998 Aug 7. PMID 9720927

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here, the authors show evidence for a short path for iron uptake from His93 on the surface to the ferroxidase center in Helicobacter pylori ferritin and Escherichia coli ferritin.
      Title: Structural Basis of Novel Iron-Uptake Route and Reaction Intermediates in Ferritins from Gram-Negative Bacteria.
    2. the data indicate that there are multiple iron-oxidation pathways in EcFtnA with O2 and H2O2 as oxidants.
      Title: Functionality of the three-site ferroxidase center of Escherichia coli bacterial ferritin (EcFtnA).
    3. results show that ftnA iron induction is independent of RyhB and instead involves direct interaction of Fe(2+)-Fur with an 'extended' Fur binding site (containing five tandem Fur boxes) located upstream (-83) of the ftnA promoter.
      Title: Induction of the ferritin gene (ftnA) of Escherichia coli by Fe(2+)-Fur is mediated by reversal of H-NS silencing and is RyhB independent.
    4. E. coli FtnA may act as an iron buffer to sequester the iron released from the disrupted iron-sulfur clusters under oxidative stress conditions and to facilitate the re-assembly of the disrupted iron-sulfur clusters under normal physiological conditions.
      Title: Escherichia coli FtnA acts as an iron buffer for re-assembly of iron-sulfur clusters in response to hydrogen peroxide stress.
    5. N-terminus verified by Edman degradation on complete protein
      Title: Overproduction, purification and characterization of the Escherichia coli ferritin.
    6. isothermal titration calorimetric equations describing a binding model for three classes of independent binding sites are reported here for the first time
      Title: Thermodynamic analysis of ferrous ion binding to Escherichia coli ferritin EcFtnA.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferric iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferric iron binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron ion sequestering activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to iron ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to iron ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ferritin iron storage protein
    NP_416418.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1988716..1989213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416418.1 ferritin iron storage protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416418.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A192C760, A0A979GFQ0, A0AA36KXX4, Q1RAN2
      Conserved Domains (1) summary
      PRK10304
      Location:1 → 165
      PRK10304; non-heme ferritin
    Nucleotide Protein
    Heading Accession and Version

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