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    hisG ATP phosphoribosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946549, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hisG
    Official Full Name
    ATP phosphoribosyltransferase
    Primary source
    ECOCYC:EG10449
    Locus tag
    b2019
    See related
    ASAP:ABE-0006713
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2014
    Summary
    ATP phosphoribosyltransferase (HisG) catalyzes the first step in the pathway of histidine biosynthesis. [More information is available at EcoCyc: EG10449].
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    Genomic context

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    Sequence:
    NC_000913.3 (2090192..2091091)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ribosome-dependent mRNA interferase toxin YoeB Neighboring gene YefM antitoxin of the YoeB-YefM toxin-antitoxin pair and DNA binding transcriptional repressor Neighboring gene his operon leader peptide Neighboring gene histidinal/histidinol dehydrogenase Neighboring gene histidinol-phosphate aminotransferase Neighboring gene imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase Neighboring gene imidazole glycerol phosphate synthase subunit HisH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new and highly sensitive assay for the ATP phosphoribosyltransferase that catalyzes the first step of histidine biosynthesis. Kronenberg HM, et al. Anal Biochem, 1975 May 12. PMID 165751
    2. Spin label studies of ATP phosphoribosyltransferase of E. coli. Tébar AR, et al. Experientia, 1977 Aug 15. PMID 196892
    3. Mn2+ electron spin resonance studies on ATP phosphoribosyltransferase from E. coli. Tebar AR, et al. Experientia, 1977 Oct 15. PMID 198234
    4. The action of inhibitors (histidine and AMP) on the ATP phosphoribosyltransferase of E. coli. Tebar AR, et al. Rev Esp Fisiol, 1978 Jun. PMID 358336
    5. Kinetic properties of ATP phosphoribosyltransferase of Escherichia coli. Tébar AR, et al. Mol Cell Biochem, 1976 Jun 15. PMID 781521

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-histidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-histidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-histidine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP phosphoribosyltransferase
    NP_416523.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2090192..2091091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416523.1 ATP phosphoribosyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416523.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A828NCH0, A0AAN3H4F5
      Conserved Domains (1) summary
      PRK00489
      Location:3 → 299
      hisG; ATP phosphoribosyltransferase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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