U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    thiD bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946459, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    thiD
    Official Full Name
    bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
    Primary source
    ECOCYC:G7135
    Locus tag
    b2103
    See related
    ASAP:ABE-0006958
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2096; thiA; thiJ
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2183716..2184516, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative sugar kinase YegV Neighboring gene putative DNA-binding transcriptional regulator YegW Neighboring gene putative glycosyl hydrolase YegX Neighboring gene hydroxyethylthiazole kinase Neighboring gene DNA-binding transcriptional repressor RcnR Neighboring gene Ni(2(+))/Co(2(+)) exporter

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. thiD locus of Escherichia coli. Imamura N, et al. Experientia, 1981 Dec 15. PMID 6276219
    2. An efficient enzymatic synthesis of thiamin pyrophosphate. Melnick JS, et al. Bioorg Med Chem Lett, 2003 Nov 17. PMID 14592524
    3. The thiJ locus and its relation to phosphorylation of hydroxymethylpyrimidine in Escherichia coli. Mizote T, et al. Microbiology (Reading), 1996 Oct. PMID 8885414
    4. The mechanism of action of bacimethrin, a naturally occurring thiamin antimetabolite. Reddick JJ, et al. Bioorg Med Chem Lett, 2001 Sep 3. PMID 11527707
    5. Structural genes for thiamine biosynthetic enzymes (thiCEFGH) in Escherichia coli K-12. Vander Horn PB, et al. J Bacteriol, 1993 Feb. PMID 8432721, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxymethylpyrimidine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxymethylpyrimidine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydroxymethylpyrimidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphomethylpyrimidine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphomethylpyrimidine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphomethylpyrimidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in thiamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine diphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thiamine salvage IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
    NP_416606.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2183716..2184516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416606.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416606.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376TCY4
      Conserved Domains (1) summary
      PRK06427
      Location:1 → 266
      PRK06427; bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.