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    eco serine protease inhibitor ecotin [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946700, updated on 3-Dec-2024

    Summary

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    Official Symbol
    eco
    Official Full Name
    serine protease inhibitor ecotin
    Primary source
    ECOCYC:EG10255
    Locus tag
    b2209
    See related
    ASAP:ABE-0007297
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2201; eti
    Summary
    Ecotin inhibits trypsin and a number of additional heterologous proteases . [More information is available at EcoCyc: EG10255].
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    Genomic context

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    Sequence:
    NC_000913.3 (2303905..2304393)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene NapA signal peptide-binding chaperone NapD Neighboring gene ferredoxin-type protein Neighboring gene uncharacterized protein YojO Neighboring gene malate:quinone oxidoreductase Neighboring gene ABC transporter family protein/microcin J25 efflux protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin. Wang CI, et al. J Biol Chem, 1995 May 19. PMID 7744876
    2. Alteration of the specificity of ecotin, an E. coli serine proteinase inhibitor, by site directed mutagenesis. Pál G, et al. FEBS Lett, 1994 Mar 28. PMID 8143850
    3. Crystallization and preliminary X-ray crystallographic analysis of the protease inhibitor ecotin. Shin DH, et al. J Mol Biol, 1993 Feb 20. PMID 8445642
    4. Trypsin display on the surface of bacteriophage. Corey DR, et al. Gene, 1993 Jun 15. PMID 8508953
    5. Stable monomeric form of an originally dimeric serine proteinase inhibitor, ecotin, was constructed via site directed mutagenesis. Pál G, et al. FEBS Lett, 1996 May 6. PMID 8647243

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.
      Title: Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.
    2. Data show that the mass difference in ecotin is likely due to the cross-linker itself.
      Title: Finding chimeras: a bioinformatics strategy for identification of cross-linked peptides.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine protease inhibitor ecotin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2303905..2304393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416713.1 serine protease inhibitor ecotin [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416713.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6G4BWX1, A0A839B0M6
      Conserved Domains (1) summary
      COG4574
      Location:1 → 162
      Eco; Serine protease inhibitor ecotin [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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