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    pdxB erythronate-4-phosphate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946785, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pdxB
    Official Full Name
    erythronate-4-phosphate dehydrogenase
    Primary source
    ECOCYC:G0-9461
    Locus tag
    b2320
    See related
    ASAP:ABE-0007663
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2314; usg-2
    Summary
    The subunit structure is not yet known. [More information is available at EcoCyc: G0-9461].
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    Genomic context

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    Sequence:
    NC_000913.3 (2436715..2437851, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA pseudouridine(38-40) synthase Neighboring gene putative semialdehyde dehydrogenase Usg Neighboring gene putative flagella assembly protein Neighboring gene putative transporter YfcJ Neighboring gene 3-oxoacyl-[acyl carrier protein] synthase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The isolation and characterization of three types of vitamin B6 auxotrophs of Escherichia coli K12. Hockney RC, et al. J Gen Microbiol, 1979 Feb. PMID 374678
    2. Multiple turnovers of the nicotino-enzyme PdxB require α-keto acids as cosubstrates. Rudolph J, et al. Biochemistry, 2010 Nov 2. PMID 20831184, Free PMC Article
    3. Metabolic relationships between pyridoxine (vitamin B6) and serine biosynthesis in Escherichia coli K-12. Lam HM, et al. J Bacteriol, 1990 Nov. PMID 2121717, Free PMC Article
    4. A new family of 2-hydroxyacid dehydrogenases. Grant GA. Biochem Biophys Res Commun, 1989 Dec 29. PMID 2692566
    5. Growth response to 4-hydroxy-L-threonine of Escherichia coli mutants blocked in vitamin B6 biosynthesis. Drewke C, et al. FEBS Lett, 1993 Mar 1. PMID 8440369

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4-phosphoerythronate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-phosphoerythronate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4-phosphoerythronate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' pyridoxal 5'-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within 'de novo' pyridoxal 5'-phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyridoxine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyridoxine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pyridoxine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    erythronate-4-phosphate dehydrogenase
    NP_416823.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2436715..2437851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416823.1 erythronate-4-phosphate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416823.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376J1T8, A0A376S9R4, A0A8S7EDP2
      Conserved Domains (1) summary
      PRK15438
      Location:1 → 378
      PRK15438; erythronate-4-phosphate dehydrogenase PdxB; Provisional
    Nucleotide Protein
    Heading Accession and Version

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