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    mlaA intermembrane phospholipid transport system - outer membrane lipoprotein MlaA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945582, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mlaA
    Official Full Name
    intermembrane phospholipid transport system - outer membrane lipoprotein MlaA
    Primary source
    ECOCYC:G7216
    Locus tag
    b2346
    See related
    ASAP:ABE-0007745
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2340; vacJ
    Summary
    First 17 aa are a type II signal peptide. [More information is available at EcoGene: EG14276]. VacJ, a putative lipoprotein in Escherichia coli has homologues among shigellae and enteroinvasive E.coli species. [More information is available at EcoCyc: G7216].
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    Genomic context

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    Sequence:
    NC_000913.3 (2464252..2465007, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene long-chain fatty acid outer membrane channel/bacteriophage T2 receptor Neighboring gene protein YfdF Neighboring gene inner membrane protein YfdC Neighboring gene tRNA-Arg

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The inner membrane protein YhdP modulates the rate of anterograde phospholipid flow in Escherichia coli. Grimm J, et al. Proc Natl Acad Sci U S A, 2020 Oct 27. PMID 33046656, Free PMC Article
    2. Osmoporin OmpC forms a complex with MlaA to maintain outer membrane lipid asymmetry in Escherichia coli. Chong ZS, et al. Mol Microbiol, 2015 Dec. PMID 26314242
    3. Multiple stressor-induced proteome responses of Escherichia coli BL21(DE3). Han KY, et al. J Proteome Res, 2008 May. PMID 18363324
    4. Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features. Yamamoto Y, et al. DNA Res, 1997 Apr 28. PMID 9205837
    5. Identification and characterization of a chromosomal virulence gene, vacJ, required for intercellular spreading of Shigella flexneri. Suzuki T, et al. Mol Microbiol, 1994 Jan. PMID 8145644

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intermembrane phospholipid transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intermembrane phospholipid transfer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell outer membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    intermembrane phospholipid transport system - outer membrane lipoprotein MlaA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2464252..2465007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416848.1 intermembrane phospholipid transport system - outer membrane lipoprotein MlaA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416848.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FZ67
      Conserved Domains (1) summary
      PRK15091
      Location:1 → 251
      PRK15091; phospholipid-binding lipoprotein MlaA
    Nucleotide Protein
    Heading Accession and Version

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