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    kgtP alpha-ketoglutarate:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947069, updated on 17-Dec-2024

    Summary

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    Official Symbol
    kgtP
    Official Full Name
    alpha-ketoglutarate:H(+) symporter
    Primary source
    ECOCYC:EG10522
    Locus tag
    b2587
    See related
    ASAP:ABE-0008515
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2585; witA
    Summary
    Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG10522]. KgtP is a proton-driven transporter for -ketoglutarate. kgtP mutants show greatly impaired growth on -ketoglutarate which can be complemented by the cloned kgtP gene . [More information is available at EcoCyc: EG10522].
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    Genomic context

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    Sequence:
    NC_000913.3 (2724448..2725746, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidyl-lysine N-acetyltransferase Neighboring gene protein PssL Neighboring gene phosphatidylserine synthase Neighboring gene DUF2279 domain-containing protein YfiM Neighboring gene protein YfiS Neighboring gene 5S ribosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Site-directed mutants of Escherichia coli alpha-ketoglutarate permease (KgtP). Seol W, et al. Biochemistry, 1992 Apr 7. PMID 1554735
    2. Membrane topology model of Escherichia coli alpha-ketoglutarate permease by phoA fusion analysis. Seol W, et al. J Bacteriol, 1993 Jan. PMID 8419306, Free PMC Article
    3. A new gene located between pss and rrnG on the Escherichia coli chromosome. Seol W, et al. J Bacteriol, 1990 Sep. PMID 2118499, Free PMC Article
    4. Membrane transport proteins: implications of sequence comparisons. Griffith JK, et al. Curr Opin Cell Biol, 1992 Aug. PMID 1419050
    5. Escherichia coli alpha-ketoglutarate permease is a constitutively expressed proton symporter. Seol W, et al. J Biol Chem, 1992 Mar 25. PMID 1556144

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables solute:monoatomic cation symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-ketoglutarate:H(+) symporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2724448..2725746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417082.1 alpha-ketoglutarate:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417082.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AR26, A0A8T5ZZD5
      Conserved Domains (1) summary
      PRK10406
      Location:1 → 432
      PRK10406; alpha-ketoglutarate transporter; Provisional
    Nucleotide Protein
    Heading Accession and Version

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