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    idi isopentenyl-diphosphate Delta-isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949020, updated on 3-Dec-2024

    Summary

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    Official Symbol
    idi
    Official Full Name
    isopentenyl-diphosphate Delta-isomerase
    Primary source
    ECOCYC:G7508
    Locus tag
    b2889
    See related
    ASAP:ABE-0009484
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2884; ygfV
    Summary
    The idi gene is nonessential. [More information is available at EcoGene: EG13072]. Isopentenyl diphosphate (IPP) isomerase (Idi) catalyzes the reversible isomerization of isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP), a key step in the biosynthesis of isoprenoids. [More information is available at EcoCyc: G7508].
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    Genomic context

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    Sequence:
    NC_000913.3 (3033065..3033613)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene urate:H(+) symporter Neighboring gene uncharacterized protein YqfG Neighboring gene protein YqfH Neighboring gene lysine--tRNA ligase Neighboring gene peptide chain release factor RF2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Catalytic mechanism of Escherichia coli isopentenyl diphosphate isomerase involves Cys-67, Glu-116, and Tyr-104 as suggested by crystal structures of complexes with transition state analogues and irreversible inhibitors. Wouters J, et al. J Biol Chem, 2003 Apr 4. PMID 12540835
    2. Primary neuroendocrine carcinoma of the skin arising from the post aural region. Kacker A, et al. J Laryngol Otol, 1992 Mar. PMID 1564387
    3. Escherichia coli open reading frame 696 is idi, a nonessential gene encoding isopentenyl diphosphate isomerase. Hahn FM, et al. J Bacteriol, 1999 Aug. PMID 10419945, Free PMC Article
    4. Crystal structure of isopentenyl diphosphate:dimethylallyl diphosphate isomerase. Durbecq V, et al. EMBO J, 2001 Apr 2. PMID 11285217, Free PMC Article
    5. Structural genomics: an approach to the protein folding problem. Montelione GT. Proc Natl Acad Sci U S A, 2001 Nov 20. PMID 11717420, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the importance of residue Tyr-104 for proper folding of Escherichia coli type I IPP isomerase
      Title: Structural role for Tyr-104 in Escherichia coli isopentenyl-diphosphate isomerase: site-directed mutagenesis, enzymology, and protein crystallography.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isopentenyl-diphosphate delta-isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isopentenyl-diphosphate delta-isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in dimethylallyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within isoprenoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    isopentenyl-diphosphate Delta-isomerase
    NP_417365.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3033065..3033613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417365.1 isopentenyl-diphosphate Delta-isomerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417365.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6D0IDY7
      Conserved Domains (1) summary
      PRK03759
      Location:1 → 180
      PRK03759; isopentenyl-diphosphate Delta-isomerase
    Nucleotide Protein
    Heading Accession and Version

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