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    pgk phosphoglycerate kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947414, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pgk
    Official Full Name
    phosphoglycerate kinase
    Primary source
    ECOCYC:EG10703
    Locus tag
    b2926
    See related
    ASAP:ABE-0009605
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2922
    Summary
    HT_Cmplx50_Mem: [More information is available at EcoGene: EG10703]. Phosphoglycerate kinase is one of the proteins induced by anaerobiosis. [More information is available at EcoCyc: EG10703].
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    Genomic context

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    Sequence:
    NC_000913.3 (3071459..3072622, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene small conductance mechanosensitive channel MscS Neighboring gene fructose-bisphosphate aldolase class II Neighboring gene D-erythrose-4-phosphate dehydrogenase Neighboring gene P-loop NTPase domain-containing protein YggC Neighboring gene fumarase E

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glyceraldehyde 3-p dehydrogenase, glycerate 3-P kinase and enolase mutants of Escherichia coli: genetic studies. Irani MH, et al. Mol Gen Genet, 1976 Apr 23. PMID 775311
    2. Isoenzymes of phosphoglycerate kinase: evolutionary conservation of the structure of this glycolytic enzyme. Watson HC, et al. Biochem Soc Trans, 1990 Apr. PMID 2379683
    3. Isolation and characterization of Escherichia coli mutants defective in enzymes of glycolysis. Irani M, et al. Biochem Biophys Res Commun, 1974 Jan. PMID 4595969
    4. Comparison of proteolytic susceptibility in phosphoglycerate kinases from yeast and E. coli: modulation of conformational ensembles without altering structure or stability. Young TA, et al. J Mol Biol, 2007 May 18. PMID 17397866
    5. Cloning and characterization of the Escherichia coli phosphoglycerate kinase (pgk) gene. Nellemann LJ, et al. Gene, 1989 Apr 15. PMID 2545537

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: '98 Escherichia coli SWISS-2DPAGE database update.
    2. Expression of pgk depends upon an RNase E segmentation process.
      Title: Characterization of the molecular mechanisms involved in the differential production of erythrose-4-phosphate dehydrogenase, 3-phosphoglycerate kinase and class II fructose-1,6-bisphosphate aldolase in Escherichia coli.
    3. Data suggest that proteolysis occurs from the globally unfolded state of E. coli phosphoglycerate kinase, but upon unfolding of only the C-domain in the Saccharomyces enzyme, with the N-domain remaining folded and consequently resistant to cleavage.
      Title: Comparison of proteolytic susceptibility in phosphoglycerate kinases from yeast and E. coli: modulation of conformational ensembles without altering structure or stability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine tetraphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoglycerate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoglycerate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoglycerate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycolytic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoglycerate kinase
    NP_417401.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3071459..3072622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417401.1 phosphoglycerate kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417401.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7D7KBH4, A0A895NZM7
      Conserved Domains (1) summary
      PRK00073
      Location:3 → 383
      pgk; phosphoglycerate kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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