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    mqsR mRNA interferase toxin MqsR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947500, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mqsR
    Official Full Name
    mRNA interferase toxin MqsR
    Primary source
    ECOCYC:G7572
    Locus tag
    b3022
    See related
    ASAP:ABE-0009925
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3013; ygiU
    Summary
    msqR is induced during biofilm formation. [More information is available at EcoGene: EG13023]. MqsR is a global regulator that controls biofilm formation by inducing motility via the two-component regulatory system QseBC. [More information is available at EcoCyc: G7572].
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    Genomic context

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    Sequence:
    NC_000913.3 (3168248..3168544, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative deoxycholate binding periplasmic protein Neighboring gene antitoxin of the MqsRA toxin-antitoxin system/DNA-binding transcriptional repressor MqsA Neighboring gene DNA-binding transcriptional repressor YgiV Neighboring gene BOF family protein YgiW

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Toxins MazF and MqsR cleave Escherichia coli rRNA precursors at multiple sites. Mets T, et al. RNA Biol, 2017 Jan 2. PMID 27858580, Free PMC Article
    2. Bacterial persistence increases as environmental fitness decreases. Hong SH, et al. Microb Biotechnol, 2012 Jul. PMID 22221537, Free PMC Article
    3. The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair. Kasari V, et al. J Bacteriol, 2010 Jun. PMID 20233923, Free PMC Article
    4. Fragmentation of Escherichia coli mRNA by MazF and MqsR. Mets T, et al. Biochimie, 2019 Jan. PMID 30315853
    5. MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli. Yamaguchi Y, et al. J Biol Chem, 2009 Oct 16. PMID 19690171, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MqsR is a noncanonical microbial RNase toxin that is inhibited by antitoxin MqsA via steric blockage of substrate binding.
      Title: MqsR is a noncanonical microbial RNase toxin that is inhibited by antitoxin MqsA via steric blockage of substrate binding.
    2. Fragmentation of Escherichia coli mRNA by MazF and MqsR.
      Title: Fragmentation of Escherichia coli mRNA by MazF and MqsR.
    3. findings show that the cyclic AMP receptor protein (CRP) indirectly upregulates mqsRA transcription; also show that CRP plays an important role in antibiotic persistence, which seems to be partially mediated through MqsRA
      Title: The cyclic AMP receptor protein (CRP) regulates mqsRA, coding for the bacterial toxin-antitoxin gene pair, in Escherichia coli.
    4. Therefore, the more toxic MqsR increases persistence by decreasing the ability of the cell to respond to antibiotic stress through its RpoS-based regulation of acid resistance, multidrug resistance and osmotic resistance systems.
      Title: Bacterial persistence increases as environmental fitness decreases.
    5. MqsA protein was cocrystallized with a 26-mer duplex DNA corresponding to the palindromic region of the mqsRA promoter
      Title: Preliminary crystallographic analysis of the Escherichia coli antitoxin MqsA (YgiT/b3021) in complex with mqsRA promoter DNA.
    6. The MqsR/MqsA TA system controls cell physiology via its own toxicity as well as through its regulation of another toxin, CspD.
      Title: Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD.
    7. The mqsR gene encodes a toxin, and ectopic expression of this gene inhibits growth and induces rapid shutdown of protein synthesis in vivo.
      Title: The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair.
    8. MqsR influences persister formation since deletion of mqsRA reduces persister cell formation and MqsR overexpression increases persister cell formation.
      Title: Toxins Hha and CspD and small RNA regulator Hfq are involved in persister cell formation through MqsR in Escherichia coli.
    9. Here, we report multiple individual and complex three-dimensional structures of MqsR and its antitoxin MqsA (B3021), which reveal that MqsR:MqsA form a novel toxin:antitoxin (TA) pair.
      Title: Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties.
    10. MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli
      Title: MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA endonuclease activity, producing 3'-phosphomonoesters IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in quorum sensing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA stability IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in single-species biofilm formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in single-species biofilm formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of toxin-antitoxin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mRNA interferase toxin MqsR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3168248..3168544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417494.1 mRNA interferase toxin MqsR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417494.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376ZHJ7
      Conserved Domains (1) summary
      cd12869
      Location:2 → 97
      MqsR; Motility quorum-sensing regulator (MqsR)
    Nucleotide Protein
    Heading Accession and Version

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