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    lpoA outer membrane lipoprotein - activator of MrcA activity [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947663, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lpoA
    Official Full Name
    outer membrane lipoprotein - activator of MrcA activity
    Primary source
    ECOCYC:G7642
    Locus tag
    b3147
    See related
    ASAP:ABE-0010343
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3135; yraM
    Summary
    First 26 aa are predicted to be a type II signal peptide. [More information is available at EcoGene: EG12778].
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    Genomic context

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    Sequence:
    NC_000913.3 (3293400..3295436)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative fimbrial adhesin YraK Neighboring gene 16S rRNA 2'-O-ribose C1402 methyltransferase Neighboring gene PF02021 family protein YraN Neighboring gene DnaA initiator-associating protein DiaA Neighboring gene division and outer membrane stress-associated lipid-binding lipoprotein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structures of the amino-terminal domain of LpoA from Escherichia coli and Haemophilus influenzae. Kelley A, et al. Acta Crystallogr F Struct Biol Commun, 2019 May 1. PMID 31045566, Free PMC Article
    2. Elongated structure of the outer-membrane activator of peptidoglycan synthesis LpoA: implications for PBP1A stimulation. Jean NL, et al. Structure, 2014 Jul 8. PMID 24954617, Free PMC Article
    3. Lipoprotein cofactors located in the outer membrane activate bacterial cell wall polymerases. Paradis-Bleau C, et al. Cell, 2010 Dec 23. PMID 21183074, Free PMC Article
    4. Regulation of peptidoglycan synthesis by outer-membrane proteins. Typas A, et al. Cell, 2010 Dec 23. PMID 21183073, Free PMC Article
    5. Prediction of lipoprotein signal peptides in Gram-negative bacteria. Juncker AS, et al. Protein Sci, 2003 Aug. PMID 12876315, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables enzyme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peptidoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in periplasmic side of cell outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in periplasmic side of cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic side of cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    outer membrane lipoprotein - activator of MrcA activity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3293400..3295436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417616.1 outer membrane lipoprotein - activator of MrcA activity [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417616.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T3UEU3
      Conserved Domains (2) summary
      COG3107
      Location:1 → 678
      LpoA; Outer membrane lipoprotein LpoA, binds and activates PBP1a [Cell wall/membrane/envelope biogenesis]
      sd00008
      Location:66 → 92
      TPR_YbbN; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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