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    aroK shikimate kinase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 2847759, updated on 3-Dec-2024

    Summary

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    Official Symbol
    aroK
    Official Full Name
    shikimate kinase 1
    Primary source
    ECOCYC:EG10081
    Locus tag
    b3390
    See related
    ASAP:ABE-0011069
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3377
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    Genomic context

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    Sequence:
    NC_000913.3 (3518543..3519064, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cell division protein DamX Neighboring gene 3-dehydroquinate synthase Neighboring gene DNA utilization protein HofQ Neighboring gene DNA utilization protein HofP Neighboring gene DNA utilization protein HofO Neighboring gene DNA utilization protein HofN

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Improving the Production of L-Phenylalanine by Identifying Key Enzymes Through Multi-Enzyme Reaction System in Vitro. Ding D, et al. Sci Rep, 2016 Aug 25. PMID 27558633, Free PMC Article
    2. Identification of a missing link in the evolution of an enzyme into a transcriptional regulator. Durante-Rodríguez G, et al. PLoS One, 2013. PMID 23526945, Free PMC Article
    3. Exploring the effects of carbon sources on the metabolic capacity for shikimic acid production in Escherichia coli using in silico metabolic predictions. Ahn JO, et al. J Microbiol Biotechnol, 2008 Nov. PMID 19047820
    4. The gene (aroK) encoding shikimate kinase I from Escherichia coli. Griffin HG, et al. DNA Seq, 1995. PMID 7612934
    5. Mecillinam resistance in Escherichia coli is conferred by loss of a second activity of the AroK protein. Vinella D, et al. J Bacteriol, 1996 Jul. PMID 8682786, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: '98 Escherichia coli SWISS-2DPAGE database update.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables shikimate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables shikimate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables shikimate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables shikimate kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chorismate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chorismate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    shikimate kinase 1
    YP_026215.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3518543..3519064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_026215.2 shikimate kinase 1 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_026215.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A418GLX6
      Conserved Domains (1) summary
      PRK05057
      Location:1 → 173
      aroK; shikimate kinase AroK
    Nucleotide Protein
    Heading Accession and Version

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