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    phnL methylphosphonate degradation complex subunit PhnL [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948612, updated on 3-Dec-2024

    Summary

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    Official Symbol
    phnL
    Official Full Name
    methylphosphonate degradation complex subunit PhnL
    Primary source
    ECOCYC:EG10721
    Locus tag
    b4096
    See related
    ASAP:ABE-0013421
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4089
    Summary
    Phosphonate utilization is cryptic in K-12. [More information is available at EcoGene: EG10721]. phnL is a member of the 14-gene phnCDEFGHIJKLMNOP operon which is involved in phosphonate uptake and metabolism and is a member of the phosphate regulon . [More information is available at EcoCyc: EG10721].
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    Genomic context

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    Sequence:
    NC_000913.3 (4317215..4317895, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase Neighboring gene aminoalkylphosphonate N-acetyltransferase Neighboring gene ribose 1,5-bisphosphate phosphokinase Neighboring gene RPnTP hydrolase Neighboring gene carbon-phosphorus lyase subunit PhnK Neighboring gene carbon-phosphorus lyase core complex subunit PhnJ Neighboring gene carbon-phosphorus lyase core complex subunit PhnI Neighboring gene carbon-phosphorus lyase core complex subunit PhnH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Five phosphonate operon gene products as components of a multi-subunit complex of the carbon-phosphorus lyase pathway. Jochimsen B, et al. Proc Natl Acad Sci U S A, 2011 Jul 12. PMID 21705661, Free PMC Article
    2. Phosphate-independent expression of the carbon-phosphorus lyase activity of Escherichia coli. Yakovleva GM, et al. Appl Microbiol Biotechnol, 1998 May. PMID 9650256
    3. Intermediates in the transformation of phosphonates to phosphate by bacteria. Kamat SS, et al. Nature, 2011 Nov 16. PMID 22089136, Free PMC Article
    4. Genes for phosphonate biodegradation in Escherichia coli. Wanner BL. SAAS Bull Biochem Biotechnol, 1992 Jan. PMID 1368181
    5. Involvement of the Escherichia coli phn (psiD) gene cluster in assimilation of phosphorus in the form of phosphonates, phosphite, Pi esters, and Pi. Metcalf WW, et al. J Bacteriol, 1991 Jan. PMID 1846145, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within organic phosphonate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organic phosphonate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in organic phosphonate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of carbon phosphorus lyase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methylphosphonate degradation complex subunit PhnL
    NP_418520.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4317215..4317895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418520.1 methylphosphonate degradation complex subunit PhnL [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418520.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3L9HUP8
      Conserved Domains (1) summary
      COG4778
      Location:1 → 226
      PhnL; Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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