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    ftsA cell division protein FtsA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944778, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ftsA
    Official Full Name
    cell division protein FtsA
    Primary source
    ECOCYC:EG10339
    Locus tag
    b0094
    See related
    ASAP:ABE-0000331
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    divA; ECK0095
    Summary
    FtsA is an essential gene. ftsA* mutants no longer require zipA. [More information is available at EcoGene: EG10339]. FtsA is an essential cell division protein which colocalizes with FtsZ to the septal ring structure; localization is FtsZ-dependent . [More information is available at EcoCyc: EG10339].
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    Genomic context

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    Sequence:
    NC_000913.3 (103982..105244)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidoglycan glycosyltransferase FtsW Neighboring gene N-acetylglucosaminyl transferase Neighboring gene UDP-N-acetylmuramate--L-alanine ligase Neighboring gene D-alanine--D-alanine ligase B Neighboring gene cell division protein FtsQ Neighboring gene cell division protein FtsZ Neighboring gene UDP-3-O-acyl-N-acetylglucosamine deacetylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Construction and Characterization of Functional FtsA Sandwich Fusions for Studies of FtsA Localization and Dynamics during Escherichia coli Cell Division. Cameron TA, et al. J Bacteriol, 2023 Jan 26. PMID 36622232, Free PMC Article
    2. Mapping and characterization of mutants of the Escherichia coli cell division gene, ftsA. Robinson AC, et al. Mol Microbiol, 1988 Sep. PMID 2846985
    3. The native form of FtsA, a septal protein of Escherichia coli, is located in the cytoplasmic membrane. Pla J, et al. J Bacteriol, 1990 Sep. PMID 2203741, Free PMC Article
    4. High-level expression of the FtsA protein inhibits cell septation in Escherichia coli K-12. Wang HC, et al. J Bacteriol, 1990 Aug. PMID 2198274, Free PMC Article
    5. How does FtsZ find its location? Voskuil JL, et al. Microb Drug Resist, 1996 Spring. PMID 9158723

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Construction and Characterization of Functional FtsA Sandwich Fusions for Studies of FtsA Localization and Dynamics during Escherichia coli Cell Division.
      Title: Construction and Characterization of Functional FtsA Sandwich Fusions for Studies of FtsA Localization and Dynamics during Escherichia coli Cell Division.
    2. Min waves without MinC can pattern FtsA-anchored FtsZ filaments on model membranes.
      Title: Min waves without MinC can pattern FtsA-anchored FtsZ filaments on model membranes.
    3. Roles of ATP Hydrolysis by FtsEX and Interaction with FtsA in Regulation of Septal Peptidoglycan Synthesis and Hydrolysis.
      Title: Roles of ATP Hydrolysis by FtsEX and Interaction with FtsA in Regulation of Septal Peptidoglycan Synthesis and Hydrolysis.
    4. SAXSDom: Modeling multidomain protein structures using small-angle X-ray scattering data.
      Title: SAXSDom: Modeling multidomain protein structures using small-angle X-ray scattering data.
    5. Protein interaction of FtsK with FTsA is essential to cell division.
      Title: FtsA G50E mutant suppresses the essential requirement for FtsK during bacterial cell division in Escherichia coli.
    6. FtsEX first interacts with FtsZ to localize to the Z ring and then interacts with FtsA to promote divisome assembly and regulate septal peptidoglycan synthesis.
      Title: How FtsEX localizes to the Z ring and interacts with FtsA to regulate cell division.
    7. Here, the authors use in vivo cross-linking to show that FtsA and ZipA indeed interact directly. They identify the exposed surface of FtsA helix 7, which also participates in binding to ATP through its internal surface, as a key interface needed for the interaction with ZipA.
      Title: Direct Interaction between the Two Z Ring Membrane Anchors FtsA and ZipA.
    8. Conversion of FtsA minirings into any type of non-miniring oligomer can promote progression of cytokinesis through FtsZ bundling and other mechanisms.
      Title: Gain-of-function variants of FtsA form diverse oligomeric structures on lipids and enhance FtsZ protofilament bundling.
    9. FtsA minirings appear to guide FtsZ to form long, often parallel, but unbundled protofilaments.
      Title: Escherichia coli FtsA forms lipid-bound minirings that antagonize lateral interactions between FtsZ protofilaments.
    10. These results implicate the actin homolog FtsA in establishment of a Z-ring scaffold, while directly remodeling the membrane and provide mechanistic insight into localized cell wall remodeling, invagination and constriction at the onset of division.
      Title: FtsA reshapes membrane architecture and remodels the Z-ring in Escherichia coli.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in FtsZ-dependent cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in FtsZ-dependent cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in division septum assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell division site IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell division site NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of divisome complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division protein FtsA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      103982..105244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414636.1 cell division protein FtsA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414636.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A418GG54, A0A5B9APS2, A0A5D8ML14, A0A8S7BTW0
      Conserved Domains (1) summary
      PRK09472
      Location:1 → 420
      ftsA; cell division protein FtsA; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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