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    panC pantothenate synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944958, updated on 3-Dec-2024

    Summary

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    Official Symbol
    panC
    Official Full Name
    pantothenate synthetase
    Primary source
    ECOCYC:EG11746
    Locus tag
    b0133
    See related
    ASAP:ABE-0000465
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0132
    Summary
    Pantothenate synthetase catalyzes the synthesis of pantothenate from -alanine and pantoate, requiring hydrolysis of ATP . [More information is available at EcoCyc: EG11746].
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    Genomic context

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    Sequence:
    NC_000913.3 (147944..148795, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene aspartate 1-decarboxylase proenzyme Neighboring gene recombination-promoting nuclease RpnC Neighboring gene 3-methyl-2-oxobutanoate hydroxymethyltransferase Neighboring gene fimbrial tip-adhesin YadC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NMR assignment of 2H, 13C and 15N labeled amino-terminal domain of apo-pantothenate synthetase from E. coli. Chakrabarti KS, et al. J Biomol NMR, 2006. PMID 16705359
    2. Enzymological properties of pantothenate synthetase from Escherichia coli B. Miyatake K, et al. J Nutr Sci Vitaminol (Tokyo), 1978. PMID 357689
    3. Pantothenate synthetase of Escherichia coli B. I. Physicochemical properties. Miyatake K, et al. J Biochem, 1976 Mar. PMID 780351
    4. The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily. von Delft F, et al. Structure, 2001 May 9. PMID 11377204
    5. Pantothenate studies. III. Description of the extracted pantothenate-synthesizing enzyme of Escherichia coli. MAAS WK. J Biol Chem, 1952 Sep. PMID 12999714

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. B-vitamin nutrition in the pea aphid-Buchnera symbiosis.
      Title: B-vitamin nutrition in the pea aphid-Buchnera symbiosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pantoate-beta-alanine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pantoate-beta-alanine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pantoate-beta-alanine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pantoate-beta-alanine ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pantothenate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pantothenate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pantothenate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pantothenate synthetase
    NP_414675.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      147944..148795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414675.1 pantothenate synthetase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414675.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9QA23
      Conserved Domains (1) summary
      PRK00380
      Location:1 → 283
      panC; pantoate--beta-alanine ligase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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