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    paoC aldehyde dehydrogenase: molybdenum cofactor-binding subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944961, updated on 3-Dec-2024

    Summary

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    Official Symbol
    paoC
    Official Full Name
    aldehyde dehydrogenase: molybdenum cofactor-binding subunit
    Primary source
    ECOCYC:G6155
    Locus tag
    b0284
    See related
    ASAP:ABE-0000988
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0283; yagR
    Summary
    AFMB Structural Genomics target Number 101 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG13557]. A YagR-YagS-YagT complex may be a heterotrimeric xanthine dehydrogenase . [More information is available at EcoCyc: G6155].
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    Genomic context

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    Sequence:
    NC_000913.3 (298736..300934, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative phage integrase Neighboring gene putative LysR family substrate binding domain-containing protein YagP Neighboring gene molybdenum cofactor insertion chaperone PaoD Neighboring gene aldehyde dehydrogenase, FAD-binding subunit Neighboring gene aldehyde dehydrogenase, Fe-S subunit Neighboring gene DUF1440 domain-containing inner membrane protein YagU

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a Rhodobacter capsulatus L-cysteine desulfurase that sulfurates the molybdenum cofactor when bound to XdhC and before its insertion into xanthine dehydrogenase. Neumann M, et al. Biochemistry, 2007 Aug 21. PMID 17649978
    2. A periplasmic aldehyde oxidoreductase represents the first molybdopterin cytosine dinucleotide cofactor containing molybdo-flavoenzyme from Escherichia coli. Neumann M, et al. FEBS J, 2009 May. PMID 19368556
    3. Molybdenum cofactor-dependent resistance to N-hydroxylated base analogs in Escherichia coli is independent of MobA function. Kozmin SG, et al. Mutat Res, 2007 Jun 1. PMID 17349664, Free PMC Article
    4. Over 1000 genes are involved in the DNA damage response of Escherichia coli. Khil PP, et al. Mol Microbiol, 2002 Apr. PMID 11967071
    5. The Escherichia coli Periplasmic Aldehyde Oxidoreductase Is an Exceptional Member of the Xanthine Oxidase Family of Molybdoenzymes. Correia MA, et al. ACS Chem Biol, 2016 Oct 21. PMID 27622978

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carboxylate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdenum ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular detoxification of aldehyde IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in outer membrane-bounded periplasmic space NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of oxidoreductase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic space NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aldehyde dehydrogenase: molybdenum cofactor-binding subunit
    NP_414818.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      298736..300934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414818.1 aldehyde dehydrogenase: molybdenum cofactor-binding subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414818.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376L1K7, A0A8S7TGW1
      Conserved Domains (1) summary
      COG1529
      Location:13 → 730
      CoxL; CO or xanthine dehydrogenase, Mo-binding subunit [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version

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