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    dgcC diguanylate cyclase DgcC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945037, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dgcC
    Official Full Name
    diguanylate cyclase DgcC
    Primary source
    ECOCYC:EG11257
    Locus tag
    b0385
    See related
    ASAP:ABE-0001336
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    adrA; ECK0380; yaiC
    Summary
    AdrA contains a GGDEF domain. [More information is available at EcoGene: EG11257]. Cellulose production is a common trait in wild isolates of Escherichia coli, but not in K-12 strains . [More information is available at EcoCyc: EG11257].
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    Genomic context

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    Sequence:
    NC_000913.3 (403703..404818)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene alkaline phosphatase Neighboring gene phosphate starvation-inducible protein PsiF Neighboring gene pyrroline-5-carboxylate reductase Neighboring gene DUF188 domain-containing protein YaiI

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Altered Regulation of the Diguanylate Cyclase YaiC Reduces Production of Type 1 Fimbriae in a Pst Mutant of Uropathogenic Escherichia coli CFT073. Crépin S, et al. J Bacteriol, 2017 Dec 15. PMID 28924030, Free PMC Article
    2. Monitoring of diguanylate cyclase activity and of cyclic-di-GMP biosynthesis by whole-cell assays suitable for high-throughput screening of biofilm inhibitors. Antoniani D, et al. Appl Microbiol Biotechnol, 2010 Jan. PMID 19707751
    3. AgfD, the checkpoint of multicellular and aggregative behaviour in Salmonella typhimurium regulates at least two independent pathways. Römling U, et al. Mol Microbiol, 2000 Apr. PMID 10760159
    4. Quantitative determination of cyclic diguanosine monophosphate concentrations in nucleotide extracts of bacteria by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry. Simm R, et al. Anal Biochem, 2009 Mar 1. PMID 19135022
    5. Local c-di-GMP Signaling in the Control of Synthesis of the E. coli Biofilm Exopolysaccharide pEtN-Cellulose. Richter AM, et al. J Mol Biol, 2020 Jul 24. PMID 32534064, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diguanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diguanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diguanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diguanylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion involved in single-species biofilm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of bacterial-type flagellum-dependent cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cellulose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    diguanylate cyclase DgcC
    NP_414919.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      403703..404818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414919.1 diguanylate cyclase DgcC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414919.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1IRU9
      Conserved Domains (1) summary
      PRK10245
      Location:6 → 371
      adrA; diguanylate cyclase AdrA; Provisional
    Nucleotide Protein
    Heading Accession and Version

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